老年高血压伴房颤患者动态动脉硬化指数、同型半胱氨酸、超敏C反应蛋白的检测及意义

AASI,Hcy and Hs-CRP in Aged Hyptensive Patients With Artial Fibrillation

目的研究老年高血压伴房颤患者动态动脉硬化指数(AASI)、同型半胱氨酸(Hcy)、血清超敏C反应蛋白(hs-CRP)的改变。方法选取老年高血压伴房颤患者(房颤组)126例,高血压窦性心律者(窦律组)117例及窦性心律非心脏病(对照组)109例。房颤组又分为阵发性房颤、持续性房颤及永久性房颤三个亚组。检测各组AASI、Hcy、hs-CRP的变化。结果房颤组AASI、Hcy、hs-CRP水平高于窦律组及对照组(P<0.05)。永久性房颤组各指标高于持续性房颤组,且均明显高于阵发性房颤组(P<0.05)。随着房颤持续时间延长,AASI、Hcy、hs-CRP水平逐渐增高,动脉硬化程度加重。结论动脉粥样硬化、炎症和氧化应激影响老年高血压伴房颤患者的病情,而且随着房颤时间的延长而加重。

Objective To investigate the changes of ambulatory arterial stiffiness index （AASI）, homocysteine （Hey） and high sensitivity C reactive protein （hs-CRP） in aged hyptensive patients with artial fibrillation. Methods Aged hyptensive patients were classified as Af group of 126 patients and sinus thythem group of 117 patients without Af history and control group of 109 patients without AF and heartdisease history. The Af group was subdivided into paroxysmal Af, persistent Af and permanent group Af as well. The levels of AASI , Hey and hs-CRP were measured. Results The levels of AASI , Hey and hs-CRP in Af group were significantly higher than those in the sinus thythem group and control group （P 〈 0.05）. Besides, those levels in permanent Af group were still higher than those in persistent Af group, and both of which higher than those in paroxysmal Af group （P 〈 0.05）, indicating the levels of AASI, Hey and hs-CRP increased gradually and atherosclerosis aggravation follow＇ing with duration of Af. Conclusion The aged hyptensive patients with artial fibrillation were impacted by atherosclerosis, inflammation and oxidative stress affected condition, and were worse with duration of atrial fibrillation.