芪龙复脉颗粒治疗气虚血瘀型脑梗死的临床研究

The Clinical Research About Cerebral Infarction by Blood Stasis Due to Qi Deficiency That Treated With Qi Long Fu Mai Morselize

目的观察芪龙复脉颗粒治疗气虚血瘀型脑梗死的临床疗效。方法对符合入选标准的脑梗死(气虚血瘀型)患者60例随机分为治疗组、对照组,各30例,两组患者均应用注射用奥扎格雷钠80 mg加入0.9%氯化钠注射液150 ml,每日1次静点;拜阿司匹林片100 mg/次,每日1次口服;阿托伐他汀钙20 mg/次,每日1次口服。同时监测生命体征、纠正水电解质紊乱,防治感染和应激性溃疡出血,支持对症治疗等。所有患者在治疗期间禁止使用其他相关药物。治疗组在基础治疗上给予芪龙复脉颗粒150 ml,每日2次温水冲服(早晚饭后各一次),每日1剂。对照组在基础治疗上给予银杏叶片,每次2片,每日2次口服。两组疗程均为30天。分别于治疗前后观察两组的临床症状、体征、血流变学指标等情况。结果两组治疗后对综合疗效进行比较,治疗组优于对照组,差异有统计学意义(P<0.05)。两组治疗前后血液流变学指标比较,差异有统计学意义(P<0.05);治疗组治疗后血液流变学各项指标低于对照组,与对照组比较,差异有统计学意义(P<0.05)。结论芪龙复脉颗粒能够改善气虚血瘀型脑梗死患者半身不遂,口眼歪斜,言语謇涩,气短乏力等症状,同时也在很大程度上降低血流变学指标,且能够防止疾病再次复发。

Objective To observe clinical effect about cerebral infarction by blood stasis due to qi deficiency that treated with qi long fu mai morselize. Methods The 60 patients （cerebral infarction by blood stasis due to qi deficiency eligible） were divided into two groups randomly that matched group and therapia group. There were 30 cases in every group. The patients in the two groups were given Cinepazide Maleate Injection 80 mg and 0.9% sodium chloride injection 150 ml, one time every day; They also were given aspirin 100 mg every time, one time every day; They were given atorvastatincalcuim 20 mg every time, one time every day as same. Patients in two groups were detected vital sign, corrected electrolyte disturbance, prevented infection and hemorrhage caused by stress ulcer,holded symptomatic treatment ect. They also prohibited cognate medicine during therapic time. Patients in the therapia group are given qi long fu mai morselize 150 ml,two times eve）, day（30 minutes after breakfast and supper）,one dose every day. Patients in the matched group are given Ginkgo Biloba Leaves Extract Tablets, 2 pills each time, two times evey day. Patients in two groups were given oral medications at the begining of the treatment,30 days for a period of treatment. Symptoms,the physical signs and hemorheology of two groups were observed and Compared both before and after treatment. Results After the treatment of the two groups, the curative effect of the treatment group was better than that of the control group, the difference was statistically significant （P 〈 0.05）. There were significant differences between the two groups before and after the treatment of hemorheology index （P 〈 0.05）. The indexes of Hemorheology in the treatment group were lower than those in the control group, and the difference was statistically significant （P 〈 0.05）. Conclusion Symptomes of hemiplegy, facial distortion,debilitation, hold-back speaking are improved when cerebral infarction patients by blood stasis due to qi deficiency that taked of qi long fu mai morselize, hemorheology results are reduced as same as posibal,and illness is prevented in the meantime.