大肠埃希菌感染临床分布及耐药性分析

Clinical Distribution and Drug Resistance of Escherichia Coli Infection

目的观察大肠埃希菌感染的临床分布情况,并统计分析大肠埃希菌对各种抗菌药物的耐药性,旨在控制医院感染。方法选取2014年1月—2016年12月从临床中分离得到的168株大肠埃希菌标本的资料作为研究对象,统计分析168株大肠埃希菌在痰液、尿液、血液及脓液等中的分布情况,同时统计大肠埃希菌对氨苄西林、甲氨苄啶等抗菌药物的耐药情况。结果 168株大肠埃希菌中,98例来自医院感染,感染率为58.3%,70例属于社区感染,感染率为41.7%,临床分布主要以痰液、尿液、血液以及脓液为主,分别占29.8%、23.8%、13.1%以及11.9%;大肠埃希菌对各种抗菌药的耐药性统计数据显示,大肠埃希菌对甲氨苄啶、环丙沙星、哌拉西林、头孢曲松、头孢噻肟的耐药率较高,分别为84.5%、81.5%、89.3%、82.1%、80.4%;大肠埃希菌对美罗培南和亚胺培南的耐药率比较低,分别为0.6%和0.6%。结论大肠埃希菌主要分布于痰液、尿液、血液以及脓液中,美罗培南和亚胺培南可作为有效的抗菌药物控制感染。

Objective To observe the clinical distribution of Escherichia coli infection and to analyze the resistance of Escherichia coli to various antimicrobial agents, aiming at controlling nosocomial infection. Methods 168 strains of Escherichia coli which were isolated from clinical from January 2014 to December 2016 were selected as study subjects. 168 strains of Escherichia coli were analyzed for sputum, urine, blood and pus In the distribution of the situation,while, Escherichia coli on ampicillin, methadiazine and other antimicrobial drug resistance was statistics. Results 168 cases of Escherichia coli, 98 cases were from the hospital infection, the infection rate was 58.3%, 70 cases were from community infection, the infection rate was 41.7%, the clinical distribution mainly were sputum, urine, blood and pus-based, respectively accounting for 29.8%, 23.8%, 13.1% and 11.9%. Escherichia coli on a variety of antimicrobial drug resistance statistics showed that Escherichia coli on amphetamine, ciprofloxacin, piperacillin, ceftriaxone, cefotaxime resistance rate were high, resistant The rates were 84.5%, 81.5%, 89.3%, 82.1% and 80.4%, respectively. The resistance rate of Escherichia coli to meropenem and imipenem were 0.6% and 0.6%, respectively. Conclusion Escherichia coli is mainly distributed in sputum, urine, blood and pus, and meropenem and imipenem can be used as an effective antimicrobial agent to control infection.