摘要
目的研究Fibulin-5在胃癌组织中的表达及其与患者预后的关系。方法选择武汉大学中南医院胃腺癌90例，采用免疫组织化学方法检测胃癌和癌旁组织中Fibulin-5蛋白的表达情况，并分析其与患者临床病理指标的关系。结果Fibulin-5在胃癌组织中的表达高于癌旁组织f细胞质：（6．2±4．2）比（5．13-3．7）；细胞核：（7．2±3．8）比（4．9±2．5），均P〈0．05]。细胞质中Fibulin-5的表达与胃癌患者的年龄正相关（r=0．213，P=0．044），与胃癌患者的总生存率负相关（25％比56％，P=0．027），并且是独立预后因子（P=0．037）。结论Fibulin-5是胃癌的一个独立预后因子，其在胃癌组织中的表达与患者生存期的缩短有关。
Objective To study the expression of Fibulin-5 in gastric cancer and its correlation with the prognosis of gastric cancer. Methods Tissue chips from 90 gastric cancer cases were used to study the expression of Fihulin-5 protein in cancer tissue and para-carcinoma tissue by immunohistochemistry, and analyze the correlation of Fibulin-5 expression and clinical pathological characteristics. Results The expression of Fibulin-5 in gastric cancer tissue was higher than that of para-carcinoma tissue [ cytoplasm ： （6.2±4.2） vs. （5.1±3.7）; nucleus：（7.2 ±3.8） vs. （4.9 ±2.5）, all P 〈0.05], which was positively related with patient＇ s age （ r = 0. 213, P = 0. 044 ） in the cytoplasm of cancerous tissue. The expression of Fibulin-5 in the cytoplasm of cancerous tissue was negatively related with patient＇s overall survival （25% vs. 56%, P = 0.027）, which was an independent predictor （P = 0.037） . Conclusion Fibulin-5 is an independent prognostic factor of gastric cancer, its expression might be related with shortend patient＇s survival time.
出处
《中华普通外科杂志》
CSCD
北大核心
2017年第3期247-250,共4页
Chinese Journal of General Surgery
