异硫氰酸酯抗肿瘤作用机制研究新进展

Advances in Research of Antitumor Mechanisms of Isothiocyanates

异硫氰酸酯(isothiocyanate,ITC)是由硫代葡萄糖苷经黑芥子酶水解形成的天然小分子,广泛存在于十字花科蔬菜中。大量研究证明异硫氰酸酯可以通过诱导肿瘤细胞周期阻滞、促进肿瘤细胞凋亡、诱导活性氧的产生等多种机制抑制肿瘤细胞在体内、体外的增殖。近期研究发现异硫氰酸酯还可以抑制肿瘤细胞侵袭转移、诱导内质网应激和细胞自噬。本文对异硫氰酸酯的抗肿瘤作用机制进行综述。

Isothiocyanates（ITCs） are naturally occurring small molecules that are generated by the enzymic hydrolysis of glucosinolate in cruciferous vegetables. Numerous studies showed that ITCs inhibit the growth of tumors by the mechanisms including inducing cell cycle arrest,promoting apoptosis and producing reactive oxygen species in vitro and in vivo. Recent studies showed that ITCs also inhibit metastasis of cancer cells,induce endoplasmic reticulum stress and autophagy. This review summarizes the antitumor mechanisms of ITCs.