摘要
目的系统评价尼可地尔对经皮冠状动脉介入治疗术后冠心病患者的心肌保护作用。方法检索Cochrane图书馆、Pubmed、CBM、CNKI数据库建立初始至今,尼可地尔干预PCI术后患者心肌损伤的临床随机对照试验。使用Rev Man5.3软件进行Meta分析。结果 Meta分析结果显示,术后血清CK-MB水平、血清c Tn I尼可地尔组显著低于对照组(P<0.001);尼可地尔组LVEF显著高于对照组,差异有统计学意义(P<0.001)。结论尼可地尔对PCI术后患者有一定心肌保护作用。
Objective To review systematically the effectiveness of the nicorandil on myocardial protection after percutaneous coronary intervention. Methods The databases of Cochrane Library, Pubmed, CBM, CNKI were retrieved with computer for collecting clinical randomized controlled trials about treatment of PCI postoperative patients with nicorandil. After cross checking, Rev Man5.3 software was used for a Meta-analysis. Results By Meta analysis, nicorandil group was significantly lower than the control group ahout the postoperative serum CK-MB level and c Tn I（P0.001）; the nicorandil group was higher in LVEF（P〈0.001）. Conclusion Nicorandil can limit the PCI-induced myocardial injury.
出处
《中国医药指南》
2017年第7期8-9,共2页
Guide of China Medicine
关键词
尼可地尔
冠状动脉介入治疗
心肌保护
META分析
Nicorandil
Percutaneous Coronary Intervention
Myocardial Protection
Meta-analysis
