FBLN-5在肿瘤形成中作用的研究进展

Research progress of FBLN-5 in the role of tumorigensis

Fibulin蛋白家族广泛存在于细胞外基质,对基底膜的形成、维持以及弹性纤维和疏松结缔组织的稳定都有着重要作用。Fibulin-5(FBLN-5)是Fibulin蛋白家族成员之一,在细胞的结构组成以及信号介导等方面都不可或缺,其缺失能够引起如内脏器官畸形等多种疾病的发生。目前研究认为,FBLN-5表达水平的变化与肺癌等多种肿瘤的发生相关,并能够影响肿瘤的增殖、侵袭及预后进展,因此有可能成为肿瘤诊断新的分子标志物。本文对FBLN-5的生物学特性与功能及其在肿瘤发生发展中的作用机制进行综述。

Fibulin protein family has widely existed in the extracellular matrix, and plays an important role in maintainthe stable of basement membrane, elastic fibers and loose connective tissue. Fibulin-5（FBLN-5） is one of the members ofthe Fibulin protein family, which is essential to the structure function and cell mediated action. The lack of FBLN- 5 willcause many diseases such as internal organ deformity. Current research suggests that changes of expression level of FBLN-5are associated with the occurrence of tumors such as lung cancer, and also can influence the tumor proliferation, invasionand prognosis, thus may become a new molecular marker for cancer diagnosis. Therefore, in this review, we summarize andupdate biological characteristics and functions of FBLN-5, and its role in the development of tumor formation mechanism.