甲状腺激素通过sirtuins影响线粒体心肌保护作用的研究进展

Advances in protective effects of thyroid hormone on myocardial mitochondria by sirtuins

国内外研究证实甲状腺激素(TH)、线粒体对心肌具有一定的保护作用。去乙酰化酶类sirtuins(SIRTs)的部分亚型也能够通过线粒体实现心肌保护作用,如减少缺血再灌注损伤、改善病理性心肌肥厚、改善心衰等。SIRTs可能通过抑制线粒体膜通道转变孔开放、抑制线粒体外膜通透性增加、维持线粒体形态调节平衡、促进线粒体的生物合成以及维持受损线粒体的自噬功能而起到心肌保护作用。同时,TH与SIRTs之间也存在相互作用。目前,线粒体在细胞凋亡、坏死中的作用以及对细胞的保护作用也越来越受关注。本文就SIRTs如何通过线粒体实现心肌保护作用及TH与SIRTs的相互作用对线粒体心肌保护作用的影响进行综述。

Many studies have confirmed that thyroid hormone（TH） and mitochondria have protective effects onmyocardium. The partial subtype of sirtuins（SIRTs） can also be able to protect myocardium by mitochondria, which includesimproving ischemia reperfusion injury, improving the pathological cardiac hypertrophy and improvement of heart failure.SIRTs can achieve the protective effect for myocardium mainly through inhibiting mitochondrial permeability transition poreand mitochondrial membrane permeabilization, maintaining balance of regulation of mitochondrial morphology, promotingmitochondrial biogenesis, maintaining the function of autophagy of impaired mitochondria. At the same time, there is aninteraction between TH and SIRTs. At present, the role of mitochondria has become more and more concerned in apoptosisand necrosis and its protective effect on cells. This review summarized the protective effect of SIRTs on myocardium throughmitochondrial and the influence of the interaction between SIRTs and TH on myocardial protection of mitochondrial.