肝纤维化新型分子诊断标志物

Novel molecular diagnostic markers for liver fibrosis

肝纤维化是各种慢性肝病进展为肝硬化的重要病理阶段,及时准确的评估肝纤维化程度,对指导慢性肝病的治疗具有重要意义。随着分子生物学技术的发展及分子诊断技术在临床的广泛应用,新型血清分子诊断标志物的检测将有助于肝纤维化的早期诊断及精准治疗。近年研究发现并经临床验证有诊断价值的血清新型分子标志物包括成纤维细胞因子、基质金属蛋白酶及其抑制物、细胞外基质相关标志物、非编码RNA等。此外,基因组学、蛋白质组学、代谢组学等分子组学检测亦有诊断意义。

Liver fibrosis is an important pathological stage for the progression of chronic liver diseases to liver cirrhosis.Timely and accurate assessment of fibrosis degree plays an important role in guiding the treatment of chronic liver diseases.With the development of molecular biology techniques and wide application of molecular diagnostic techniques,the measurement of novel serum molecular diagnostic markers may contribute to the early diagnosis and precise treatment of liver fibrosis.A number of novel serum molecular markers with a diagnostic value have been identified,including fibroblast factor,matrix metalloproteinases and their inhibitors,extracellular matrix-related markers,and non-coding RNAs.In addition,genomics,proteomics,and metabolomics also have certain diagnostic values.