抗菌药物在肝硬化患者中的应用

Application of antibacterial agents in patients with liver cirrhosis

肝硬化患者常伴有细菌感染,最常见的细菌感染类型为自发性细菌性腹膜炎。临床上,抗菌药物广泛用于自发性细菌性腹膜炎的防治。此外,抗菌药物也可降低肝硬化上消化道出血患者的再出血率及病死率。然而,为避免细菌耐药,合理应用抗菌药物是必要的。综述了抗菌药物在肝硬化患者中的主要适应证和耐药情况。

Bacterial infection is frequently seen in patients with liver cirrhosis,and the most common type of bacterial infection is spontaneous bacterial peritonitis（SBP）.In clinical practice,antibacterial agents are widely used in the treatment of SBP.In addition,antibacterial agents can reduce rebleeding and mortality rates in patients with upper gastrointestinal bleeding.However,in order to avoid bacterial resistance,the appropriate use of antibacterial agents is very important.This article reviews the indications and resistance of antibacterial agents in patients with liver cirrhosis.