对影响早期子宫颈癌患者手术治疗的高危风险因素临床研究

Effects of high-risk factors on clinicaloutcomes of early-stagecervical cancer patients after surgical

目的探讨分析影响早期子宫颈癌患者手术治疗效果的高危风险因素,并观察上述因素对患者生存结局的影响。方法采用回顾性分析方法,选取早期(ⅠB~ⅡB期)宫颈癌患者98例,均经病理学证实且接受手术治疗。通过检测手术病理学风险因素,依据存在的风险因素数目将患者分组,组间比较手术疗效。结果存在1项风险因素者(单项组)33例(33.7%),存在多项(≥2项)者(多项组)23例(23.5%)。随访显示,多项组局部复发率和远处转移率高于单项组(P<0.05),而总生存期(OS)及无瘤生存期(DFS)低于单项组(P<0.05)。多项组中,接受同步放化疗者生存期均优于单纯放疗者(P<0.05)。结论在接受手术治疗的早期宫颈癌患者中,多项风险因素可降低手术效果和生存结局。同步放化疗有助于提高治疗效果。

Objective To investigate the effects of high-risk factors on clinical outcomes of early-stage cervical cancer patients after surgical. Methods Totally 98 cases of pathologically confirmed early-stage cervical cancer patients were selected,and all received surgical treatment. Thesurgical-pathological risk factors of patients were analyzed and grouping according to the number of high-risk factors. The surgical results of groups were compared. Results There were 1 risk factors（single group） in 33 cases（33. 7%）,multiple high-risk factors（≥2）（multiple group） in23 cases（23. 5%）.The local recurrence rate and distant metastasis rate of multiple group were higher than that of single group（P〈0. 05）,but the overall survival（OS） and disease-free survival（DFS） were lower than those the single group（P〈0. 05）. The survival time in patients treated with synchronism chemoradiation were better than those with radiotherapy alone in multiple group（P〈0. 05）. Conclusion Multiple risk factors can reduce surgical outcomes and survival outcomes of early-stage cervical cancer patients after surgical,and synchronism chemoradiation is helpful to improve clinical outcomes.