喜炎平注射液联合阿奇霉素序贯疗法对肺炎支气管肺炎患者血清IL-33、IL-6及TNF-α水平的影响

Effect of Xiyanping Injection combined with Azithromycin Sequential Therapy on the Serum IL-33, IL-6 and TNF-α Levels in Patients with Bronchopneumonia

目的:探讨喜炎平注射液联合阿奇霉素序贯疗法对肺炎支气管肺炎患者血清白介素-6(IL-6)、白介素-33(IL-33)、肿瘤坏死因子-α(TNF-α)水平的影响。方法:收集我院就诊或住院治疗的840例支气管肺炎患者,随机分为实验组和对照组,每组420例。对照组患者给予阿奇霉素治疗。实验组在对照组基础上给予喜炎平静脉滴注治疗。观察并比较两组患者血清白介素-6(IL-6)、白介素-33(IL-33)、肿瘤坏死因子-α(TNF-α)水平以及临床疗效。结果:与治疗前相比,两组患者治疗后血清IL-6、IL-33、TNF-α水平均显著下降(P<0.05);与对照组相比,实验组患者的血清IL-6、IL-33、TNF-α水平较低(P<0.05),临床治疗有效率较高(P<0.05)。结论:喜炎平注射液联合阿奇霉素序贯疗法能够提高肺炎支气管肺炎患者的临床疗效,可能与其降低患者血清IL-33、IL-6及TNF-α水平有关。

Objective： To investigate the effect of Xiyanping injection combined with Azithromycin Sequential Therapy on the serum IL-33, IL-6 and TNF-a levels in patients with bronchopneumonia. Methods： 840 cases of bronchopneumonia in our hospital were selected and randomly divided into the experimental group and control group with 420 cases in each group. The control group was given azithromycin, while the experimental group was treated on the base of control group with Xiyanping. After treatment, the serum interleukin-6（IL-6）, interleukin-33（IL-33）, tumor necrosis factor-α（TNF-α） levels and clinical curative effect were detected and compared between two groups. Results： Compared with before treatment, the IL-6, IL-33, TNF-levels of both groups were significantly decreased after treatment（P〈0.05）. Compared with the control group, the serum IL-6, IL-33 levels of TNF-a levels of experimental group were obviously lower（P〈0.05）, the clinical effective rate was higher（P〈0.05）. Conclusion： Xiyanping injection combined with Azithromycin Sequential Therapy could effectively enhance the clinical curative effect of patients with bronchopneumonia, which might be related to the decrease of serum IL-33, IL-6 and TNF-a levels.