雷公藤多甙片与甲氨喋呤联合治疗类风湿关节炎的临床疗效及对炎症因子的影响

Clinical Efficacy Tripterygium and Methotrexate in the Treatment of Rheumatoid Joints and its Influence on Inflammatory Factors

目的:研究雷公藤多苷片联合甲氨蝶呤治疗类风湿关节炎(RA)的临床疗效及对血清炎症因子的影响。方法:选取2014年1月-2015年8月我院收治的RA患者60例,按治疗方法的不同分为观察组和对照组各30例,观察组应用雷公藤多苷片联合甲氨蝶呤治疗,对照组单纯应用甲氨蝶呤治疗,对比两组的临床疗效及治疗前后临床症状、红细胞沉降率(ESR)、C反应蛋白(CRP)及类风湿因子(RF)水平。结果:观察组的总有效率为93.33%,明显高于对照组的73.33%(P<0.05);治疗后观察组的临床症状(晨僵时间、关节压痛及肿胀数、关节疼痛度及肿胀指数)均较对照组明显改善(P<0.05);治疗后两组血清ESR、CRP、RF水平均降低,且观察组明显低于对照组(P<0.05);观察组不良反应率为13.33%,低于对照组的10.00%,差异无统计学意义(P>0.05)。结论:雷公藤多苷片联合甲氨蝶呤治疗RA能够有效控制炎症反应,改善临床症状,临床疗效显著,且不增加副反应,是一种安全可靠的联合治疗方案,值得推广应用。

Objective： To inveterate the clinical efficacy tripterygium and methotrexate in the treatment of rheumatoid joints（RA）and its influence on inflammatory factors. Methods： 60 patients with RA who admitted to our hospital form January 2014 to August 2015 were collected, all were assigned into observation group and control group according to the different treatment methods, 30 cases in each group. The observation group received Tripterygium glycosides tablet combined methotrexate methotrexate therapy, the control group received simple methotrexate therapy, the clinical efficacy and improvement of clinical symptoms, ESR, CRP, RF, before and after treatment in the two groups were compared. Results： The total effective observation group was 93.33%, significantly higher than 73.33%in the control group（P0.05）; clinical observation group after treatment（duration of morning stiffness, joint tenderness and swelling the number of degrees and joint pain swelling index） than the control group improved significantly（P0.05）. The serum levels of ESR,CRP and RF were decreased in the two groups after treatment, and the observation group was significantly lower than that of the control group（P0.05）. adverse reactions observed group was 13.33%, and 10.00% as compared to the control group showed no significant difference（P0.05）. Conclusion： Tripterygium glycosides tablet in combination with methotrexate treatment of RA can effectively control the inflammatory response and improved clinical symptoms, the clinical efficacy is significant, without increasing side effects, it is a safe and reliable combination therapy, it should be widely applied.