巨噬细胞在动脉粥样硬化形成中的作用

The Role of Macrophages in the Formation of Atherosclerosis

巨噬细胞是机体免疫系统的重要一员,具有趋化、吞噬、免疫及分泌等功能。在动脉粥样硬化(atherosclerosis,AS)形成过程中,巨噬细胞受低密度脂蛋白氧化修饰过程中的炎性因子趋化,大量吞噬氧化低密度脂蛋白,变为"泡沫细胞",进而导致动脉粥样硬化病变,并通过免疫及分泌功能生成肿瘤坏死因子α等物质加速病变的进展,其功能变化与动脉粥样硬化形成和发展息息相关。ADRP作为PAT家族蛋白中的一员,因在脂滴形成中的重要作用而受到广泛关注。ADRP是动脉粥样硬化过程中的一个关键分子,不仅在病变中起着提高炎症反应与调节脂质代谢的双重作用,而且通过限制泡沫细胞的形成,而影响了动脉粥样硬化的走向。

Macrophages are important cells of the immune system, which have the chemotaxis, phagocytosis, immune, secretion and other functions. In the process of atherosclerosis, macrophages phagocytose the ox-LDL, which the process of inflammatory cytokines chemotaxis, phagocytosis lot of oxidized LDL and become ＂foam cells＂, which leads to atherosclerotic lesions and generate substances such as tumor necrosis factor-α secreted by immune function and accelerate the progress of disease, a member with chemotaxis, phagocytosis, and secretion of immune function, inflammatory cytokines by oxidative modification of LDL occurs during chemotaxis, phagocytosis lot of oxidized low-density lipoprotein, become ＂foam cells＂, which led to atherosclerotic lesions, and generate substances such as tumor necrosis factor-α accelerates the progress of disease through immunization and secretory functions which change and atherosclerosis formation and development are closely related. ADRP as the PAT protein, a member of the family, because of the important role in the formation of lipid droplets and attracted widespread attention. ADRP is atherosclerosis, a key molecule in the process, not only in improving inflammatory lesions plays a dual role and regulation of lipid metabolism, but also by limiting the formation of foam cells, which will affect the trend of atherosclerosis.