MAPKs信号通路在动脉粥样硬化发生发展中的调控作用

MAPKs Signal Transduction Pathways in the Development of Athrosclerosis

丝裂原激活蛋白激酶(mitogen-activated protein kinases,MAPKs)信号通路是生物体内重要的信号传导通路,其主要参与调控细胞的增殖、生长、分化、凋亡和炎症反应等多种生理病理过程。MAPKs信号通路在多种心血管疾病的病理过程中起着重要调控作用。动脉粥样硬化(athrosclerosis,AS)所致的各种急重症严重危害人类的健康,发病率呈逐年上升的趋势,但是动脉粥样硬化发生发展的分子机制尚不完全清楚。近年来,MAPKs信号通路在动脉粥样硬化(athrosclerosis,AS)的发生发展中的作用已成为是研究的热点。

Mitogen-activated protein kinase（MAPK） signal transduction pathways are ubiquitous and highly evolutionarily conserved mechanisms of eukaryotic cell regulation, controling essential processes in all eukaryotic cells, including cell proliferation, development, differentiation, apoptosis and inflammation reaction. MAPK signaling cascades likely play an important role in the pathogenesis of cardiac and vascular disease. Atherosclerosis is a chronic disease of the arterial wall, and a leading cause of death and loss of productive life years worldwide, while its molecular mechanism of development is unclear. Recently, more attention is paid to its functions in the atherosclerotic development.