瘦素对骨关节炎影响的研究进展

The Research Progress of Leptin Effect on Osteoarthritis

瘦素(Leptin)是脂肪因子的一种,可以在骨关节炎(OA)患者的血浆、滑液、软骨中被检测到。OA是一种最常见的关节疾病,其可以发生于全身的多个关节,以骨质和滑膜组织新陈代谢的改变、关节软骨的破坏和由此引起的关节软骨的减少为特征。瘦素是一种由肥胖(0b)基因编码的一个小的非糖基化肽激素。最开始,瘦素仅仅被认为是一种脂肪细胞源性的小分子(16KD),在下丘脑中枢水平作为一个饱感因子介导食物摄入量减少,并增加能量的消耗。现在已经发现,瘦素在机体内可发挥多种生理作用,并与OA病情有关。本文通过对瘦素与OA、软骨、肥胖、生物标志物、脂联素等之间的联系做一综述,以了解瘦素与OA之间的联系,为OA的治疗方面的进一步研究提供帮助。

Leptin is a kind of fat factors, which can be detected in plasma, synovial fluid, cartilage of patients with osteoarthritis（OA）. Osteoarthritis is the most common joint disease, which can be detected in multiple joints with the characteristic of articular cartilage inflammation, damage, bone and synovial tissue metabolism and the reduction of articular cartilage caused by pathological changes of these lesions. Leptin is a small non glycosylated peptide hormone encoded by the obese（0b） gene. Leptin is only thought to be a fat cell derived small molecule（16KD）, which acts as a satiety factor in the hypothalamic central level to reduce food intake and increase energy consumption. It has been demonstrated that leptin plays a variety of physiological functions and relates to the condition of OA in the body. The association among leptin, cartilage, obesity, biomarkers and adiponectin is reviewed in this article to understand the relationship between leptin and OA. It will be meaning for the treatment of OA.