完整肠系膜切除术在大肠癌治疗中的临床作用探讨

Exploration on clinical effect of complete mesocolic excision in the treatment of colorectal cancer

目的探讨在大肠癌治疗中应用完整肠系膜切除术的临床作用。方法 66例大肠癌患者,利用抽签法分为研究组与对照组,每组33例。对照组患者给予传统大肠癌根治术治疗,研究组患者给予完整结肠系膜切除术治疗,对比分析两组患者治疗后的临床效果。结果研究组患者临床总有效率(96.97%)高于对照组(69.70%),差异具有统计学意义(χ~2=8.8364,P<0.05)。研究组患者的并发症发生率为6.06%、复发率为3.03%,均低于对照组的24.24%、18.18%,1年生存率(90.91%)高于对照组(66.67%),差异均具有统计学意义(χ~2=4.2429、3.9952、5.8022,P<0.05)。研究组患者的术中出血量、肛门排气时间、拔管时间、住院时间、淋巴结清扫数均优于对照组,差异均具有统计学意义(t=14.7631、13.1304、11.0472、12.3476、16.0848,P<0.05)。结论在大肠癌治疗中应用完整肠系膜切除术的临床疗效较为显著,具有临床推广意义。

Objective To explore the clinical effect of complete mesocolic excision applied in the treatment of colorectal cancer. Methods A total of 66 colorectal cancer patients were divided by lottery method into research group and control group, with 33 cases in each group. The control group received traditional resection of colorectal cancer for treatment, and the research group received complete mesocolic excision for treatment. Clinical effects after treatment were compared and analyzed in two groups. Results The research group had total clinical efective rate as 96.97%, which was higher than 69.70% in the control group, and the difference had statistical significance （X2=8.8364, P〈0.05）. The research group had lower incidence of complications as 6.06%, recurrence rate as 3.03% than 24.24% and 18.18% in the control group, higher survival rate in 1 year as 90.91% than 66.67% in the control group. All their differences had statistical significance （X2=4.2429, 3.9952, 5.8022, P〈0.05）. The research group had better intraoperative bleeding volume, anus exhaust time, extubation time, hospital stay time, number of lymph node cleaning than those of the control group, and all their differences had statistical significance （t=14.7631, 13.1304, 11.0472, 12.3476, 16.0848, P〈0.0~）. Conclusion Application of complete mesocolic excision shows significant clinical effect for the treatment of colorectal cancer, and it has promotion significance in clinic.