奥曲肽、垂体后叶素治疗肝硬化上消化道出血临床效果对比分析

Comparative analysis of clinical effects by octreotide and pituitrin in the treatment of liver cirrhosis upper gastrointestinal hemorrhage

目的对比分析奥曲肽、垂体后叶素治疗肝硬化上消化道出血临床效果。方法 160例肝硬化上消化道出血患者,按照随机数字表法分为对照组和试验组,各80例。对照组患者采用垂体后叶素治疗,试验组患者采用奥曲肽治疗,比较两组治疗总有效率、止血时间和不良反应发生率。结果试验组治疗总有效率为96.3%,明显高于对照组85.0%,差异具有统计学意义(χ~2=5.9586,P<0.05)。试验组止血时间为(20.9±10.7)h,显著短于对照组的(35.8±12.3)h,差异具有统计学意义(t=8.1747,P<0.05)。试验组不良反应发生率为5.0%,低于对照组的16.3%,差异具有统计学意义(χ~2=5.3311,P<0.05)。结论奥曲肽和垂体后叶素对肝硬化上消化道出血均具有良好的治疗效果,但奥曲肽效果确切,安全性高,临床可将其作为优先选择的治疗药物积极推广。

Objective To comparatively analyze clinical effects by octreotide and pituitrin in the treatment of liver cirrhosis upper gastrointestinal hemorrhage. Methods A total of 160 patients with liver cirrhosis upper gastrointestinal hemorrhage were divided by random number table into control group and experimental group, with 80 cases in each group. The control group received pituitrin for treatment, and the experimental group received octreotide for treatment. Comparison was made on total effective rate in treatment, hemostasis time and incidence of adverse reactions between the two groups. Results The experimental group had obviously higher total effective rate in treatment as 96.3% than 85.0% in the control group, and their difference had statistical significance （X2=5.9586, P〈0.05）. The experimental group had hemostasis time as （20.9 ± 10.7） h, which was much shorter than （35.8 ±12.3） h in the control group, and the difference had statistical significance （t=8.1747, P〈0.05）. The experimental group had lower incidence of adverse reactions as 5.0% than 16.3% in the control group, and the difference had statistical significance （X2=5.3311, P〈0.05）. Conclusion Octreotide and pituitrin can both provide excellent curative effect for liver cirrhosis upper gastrointestinal hemorrhage, while octreotide shows more precise effect and higher safety. It can be taken as the preferred medication for active clinical promotion.