幽门螺杆菌阳性胃溃疡应用序贯疗法和标准三联疗法治疗的比较

Comparison of sequential therapy and standard triple therapy applied in the treatment of helicobacter pylori positive peptic ulcers

目的比较幽门螺杆菌(Hp)阳性胃溃疡应用序贯疗法和标准三联疗法治疗的效果。方法 96例Hp阳性胃溃疡患者,随机分为对照组和观察组,各48例。对照组采用标准三联疗法治疗,观察组采用序贯疗法治疗,综合评价两组患者的疗效。结果观察组Hp根除率为81.25%,显著高于对照组的58.33%,差异有统计学意义(P<0.05);两组患者的不良反应发生率比较差异无统计学意义(P>0.05)。观察组临床总有效率为81.25%,显著高于对照组的54.17%,差异有统计学意义(P<0.05)。结论序贯疗法治疗Hp阳性胃溃疡的效果优于标准三联疗法,前者在提高Hp根除率、抑制病情复发方面具有优势,且安全性尚可。

Objective To compare the effect of sequential therapy and standard triple therapy applied in the treatment of helicobacter pylori （Hp） positive peptic ulcers. Methods A total of 96 Hp positive peptic ulcers patients were randomly divided into control group and observation group, with 48 cases in each group. The control group received standard triple therapy, and the observation group received sequentiM therapy. Curative effect was comprehensively evaluated in two groups. Results The observation group had obviously higher rate of Hp eradication as 81.25% than 58.33% in the control group, and the difference had statistical significance （P〈0.05）. There was no statistically significant difference in incidence of adverse reactions between two groups （P〉0.05）. The observation group had obviously higher total clinical effective rate as 81.25% than 54.17% in the control group, and the difference had statistical significance （P〈0.05）. Conclusion Sequential therapy provides better effect than standard triple therapy in the treatment of Hp positive peptic ulcers, which has advantages in increasing rate of Hp eradication and inhibiting recurrence of disease, and it is safe.