帕罗西汀联合认知行为疗法治疗广泛性焦虑障碍患者的疗效分析

Analysis of curative effect by paroxetine combined with cognitive behavior therapy in the treatment of generalized anxiety disorder patients

目的分析帕罗西汀联合认知行为疗法治疗广泛性焦虑障碍患者的临床疗效。方法 64例广泛性焦虑障碍患者,依据随机数字表法分为观察组和对照组,各32例。两组患者均选择帕罗西汀进行治疗,观察组患者在此基础上联合认知行为疗法进行治疗,比较两组患者的临床治疗效果。结果观察组患者治疗前后汉密尔顿焦虑量表(HAMA)评分分别为(33.04±4.25)、(8.80±1.05)分,对照组患者治疗前后HAMA评分分别为(32.48±3.82)、(13.24±2.08)分,治疗前两组HAMA评分比较差异无统计学意义(t=0.5544,P>0.05);治疗后观察组HAMA评分低于对照组,差异具有统计学意义(t=10.7795,P<0.05)。观察组患者治疗前后功能大体评定量表(GAF)评分分别为(51.74±6.64)、(80.38±7.17)分,对照组患者治疗前后GAF评分分别为(51.86±6.88)、(70.28±6.11)分,治疗前两组GAF评分比较差异无统计学意义(t=0.0710,P>0.05);治疗后观察组GAF评分高于对照组,差异具有统计学意义(t=6.0650,P<0.05)。结论广泛性焦虑障碍患者采用帕罗西汀联合认知行为疗法进行治疗,可有效改善临床症状。

Objective To analyze clinical effect by paroxetine combined with cognitive behavior therapy in the treatment of generalized anxiety disorder patients. Methods A total of 64 patients with generalized anxiety disorder were divided by random number table into observation group and control group, with 32 cases in each group. Both groups received paroxetine for treatment, and the observation group also received additional cognitive behavior therapy for combined treatment. Clinical effects were compared between the two groups. Results The observation group had Hamilton anxiety scale （HAMA） scores before and after treatment respectively as （33.04 ± 4.25） and （8.80 ± 1.05） points. The control group had HAMA scores before and after treatment respectively as （32.48 ±3.82） and （13.24 ± 2.08） points. There was no statistically significant difference of HAMA score before treatment between the two groups （t=0.5544, P〉0.05）. After treatment, the observation group had lower HAMA score than the control group, and the difference had statistical significance （t=10.7795, P〈0.05）. The observation group had global assessment function （GAF） scores before and treatment respectively as （51.74 ± 6.64） and （80.38 ± 7.17） points. The control group had GAF scores before and after treatment respectively as （51.74 ± 6.64） and （80.38 ± 7.17） points. There was no statistically significant difference of GAF score before treatment between the two groups （t=0.0710, P〉0.05）. After treatment, the observation group had higher GAF score than the control group, and their difference had statistical significance （t=6.0650, P〈0.05）. Conclusion Implement of paroxetine combined with cognitive behavior therapy in treating generalized anxiety disorder patients can effectively improve their clinical symptoms.