垂体后叶素与硝普钠联用治疗支气管扩张咯血的临床分析

Clinical analysis of pituitrin combined with sodium nitroprusside in the treatment of emoptysis caused by bronchiectasis

目的探讨垂体后叶素与硝普钠联用治疗支气管扩张咯血的临床效果。方法 130例支气管扩张咯血患者为研究对象,将其随机分为观察组及对照组,各65例。观察组给予垂体后叶素与硝普钠联用治疗,对照组给予单用垂体后叶素治疗,对两组治疗效果进行对比和观察。结果观察组治疗总有效率90.77%显著高于对照组72.31%,差异具有统计学意义(P<0.05)。观察组患者咯血停止时间(3.2±1.3)d短于对照组(5.2±1.0)d,差异具有统计学意义(P<0.05)。治疗后,观察组肺动脉压(28.67±4.12)mm Hg(1mm Hg=0.133 kPa)明显低于对照组(33.55±4.08)mm Hg,差异具有统计学意义(P<0.05)。观察组不良反应发生率7.69%明显低于对照组20.00%,差异具有统计学意义(P<0.05)。结论垂体后叶素与硝普钠联用治疗支气管扩张咯血的临床效果显著,不良反应发生率低,因此该种方法值得在临床上大力推广使用。

Objective To explore the clinical effect of pituitrin combined with sodium nitroprusside in the treatment of emoptysis caused by bronchiectasis. Methods A total of 130 emoptysis caused by bronehiectasis patients as study subjects were randomly divided into observation group and control group, with 65 cases in each group. The observation group receivedpituitrin combined with sodium nitroprussidefor treatment, and the control group received simply pituitrinfor treatment. The treatment effect was compared and observed in two groups. Results The observation group hadtotal effective rate.as 90.77%, which was obviously higher than 72.31%in the control group, and thedifference had statistical significance （P〈0.05）. The observation group had emoptysis stopped time as （3.2 ± 1.3） d, which was shorter than （5.2 ± 1.0） din the control group, and thedifference had statistical significance （P〈0.05）. After treatment, the observation group＇hadpulmonary artery pressure as （28.67 ± 4.12） mm Hg （1 mm Hg=0.133 kPa）, which wasobviously lower than （33.55 ± 4.08） mm Hg in the control group, and the difference had statistical significance （P〈0.05）. The observation group hadincidence of adverse reactionsas 7.69%, which was obviously lower than 20.00% in the control group, and the difference had statistical significance （P〈0.05）. Conclusion Pituitrin combined with sodium nitroprusside showssignificant clinical effectin the treatment of emoptysis caused by bronchiectasis with low incidence of adverse reactions, therefore this method is worthpromotion and use in clinic.