摘要
高氧可引起体内活性氧的增加,导致多种细胞和组织的损伤。NF-κB是一种氧化应激敏感性转录调控因子,高氧可以通过对NF-κB的调控,从而调控不同的下游基因和蛋白。本文从高氧介导的活性氧产生、上下游通路对NF-κB的调控及细胞成熟分化对NF-κB的研究进展做一综述。
Hyperoxia can cause an increase in reactive oxygen species in vivo,resulting in a variety of cell and tissue damage.NF-κB is an oxidative stress-sensitive transcription factor.The influnence of hyperoxia on NF-κB exerts regulation of different downstream genes and proteins,but the exact mechanism remains unclear.This article reviews the extensive studies including reactive oxygen species generation,upstream and downstream pathway and cell maturation and differentiation of NF-κB in hyperoxia environment.
出处
《实用药物与临床》
CAS
2017年第3期333-338,共6页
Practical Pharmacy and Clinical Remedies
基金
国家自然科学基金(30871158
81170604)
辽宁省教育厅科学计划研究项目(L K201620)
盛京自由研究者