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高氧与核因子Kappa B

Hyperoxia and NF-κB
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摘要 高氧可引起体内活性氧的增加,导致多种细胞和组织的损伤。NF-κB是一种氧化应激敏感性转录调控因子,高氧可以通过对NF-κB的调控,从而调控不同的下游基因和蛋白。本文从高氧介导的活性氧产生、上下游通路对NF-κB的调控及细胞成熟分化对NF-κB的研究进展做一综述。 Hyperoxia can cause an increase in reactive oxygen species in vivo,resulting in a variety of cell and tissue damage.NF-κB is an oxidative stress-sensitive transcription factor.The influnence of hyperoxia on NF-κB exerts regulation of different downstream genes and proteins,but the exact mechanism remains unclear.This article reviews the extensive studies including reactive oxygen species generation,upstream and downstream pathway and cell maturation and differentiation of NF-κB in hyperoxia environment.
出处 《实用药物与临床》 CAS 2017年第3期333-338,共6页 Practical Pharmacy and Clinical Remedies
基金 国家自然科学基金(30871158 81170604) 辽宁省教育厅科学计划研究项目(L K201620) 盛京自由研究者
关键词 核因子KAPPA B 高氧 活性氧 Nuclear factor Kappa B Hyperoxia ROS
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  • 1张向峰,Hussein D.Foda.骨桥蛋白在高氧所致急性肺损伤中的作用及机制的初步探讨[J].中华结核和呼吸杂志,2006,29(6):385-389. 被引量:4
  • 2张向峰,丁少芳,高元明,梁瑛,Foda H D.多种基质金属蛋白酶在高氧所致急性肺损伤中的表达[J].中国危重病急救医学,2006,18(8):449-451. 被引量:17
  • 3Wolfgang THOMAS,Christian P SPEER,钱莉玲,邓芳明.支气管肺发育不良的防治——证据及临床应用[J].中国当代儿科杂志,2007,9(3):264-277. 被引量:3
  • 4Britton JR. Altitude, oxygen and the definition of bronchopulmonary dysplasia[J]. J Perinatol, 2012, 32(11): 880-885.
  • 5Guo WA, Knight PR, Raghavendran K. The receptor for advanced glycation end products and acute lung injury/acute respiratory distress syndrome[J]. Intensive Care Med, 2012, 38(10): 1588-1598.
  • 6Christie JD, Shah CV, Kawut SM, et al. Plasma levels of receptor for advanced glycation end products, blood transfusion, and risk of primary graft dysfunction[J]. Am J Respir Crit Care Med, 2009, 180(10): 1010-1015.
  • 7Tian Z, Li Y, Ji P, et al. Mesenchymal stem cells protects hyperoxia-induced lung injury in newborn rats via inhibiting receptor for advanced glycation end-products/nuclear factor kappaB signaling[J]. Exp Biol Med(Maywood), 2013, 238(2): 242-247.
  • 8Matute-Bello G, Winn RK, Jonas M, et al. Fas (CD95) induces alveolar epithelial cell apoptosis in vivo: implications for acute pulmonary inflammation[J]. Am J Pathol, 2001, 158(1): 153-161.
  • 9Ambalavanan N, Mourani P. Pulmonary hypertension in bronchopulmonary dysplasia[J]. Birth Defects Res A Clin Mol Teratol, 2014, 100(3): 240-246.
  • 10Yatime L, Andersen GR. Structural insights into the oligomerization mode of the human receptor for advanced glycation end-products[J]. FEBS J, 2013, 280(24): 6556-6568.

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