摘要
尿酸代谢异常被看作是高尿酸血症和痛风的主要病因之一,尿酸盐转运蛋白的功能异常是导致尿酸代谢异常的最主要原因,其影响了肾脏对尿酸的重吸收和排泄功能。近年来三磷酸腺苷结合盒转运蛋白G2(ATP-binding cassette superfamily G member 2,ABCG2)作为最受关注的尿酸盐转运蛋白,得到国外国内学者的较多研究报道。ABCG2定位在细胞膜,表达在近曲小管上皮细胞刷状缘侧,可以转运尿酸。其功能性障碍阻碍了肾脏和肠道对尿酸的排泄,从而引起高尿酸血症并引发痛风。本文就ABCG2基因单核苷酸多态性与痛风发病相关性的研究进展作一综述。
Abnormal uric acid metabolism is the main cause of hyperuricemia and gout. A variety of urate transporters affect the absorption and excretion of uric acid. In recent years, scholars have paid close attention to the ATP-binding cassette superfamily G member 2（ABCG2）. ABCG2 is expressed on the cell membrane and in the brush border of the epithelial cells lining the proximal convoluted tubule and can transport uric acid. The functional obstacle hampering the kidney and intestine in the excretion of uric acid, causes high blood uric acid and gout. In this review, the research progress of the correlation between ABCG2 gene single nucleotide polymorphisms and the incidence of gout will be reviewed.
作者
闻海丰
宋春蒙
石豪妍
温婵
秦瑾
冯忠军
WEN Haifeng SONG Chunmeng SHI Haoyan WEN Chan QIN Jin FENG Zhongjun(Laboratory, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China, 050051 Laboratory, the First Hospital of Yongnian County, Handan, Hebei, China, 057150 Infection Control Department, Children＇s Hospital of Hebei Province, Shijiazhuang, Hebei, China, 050051 Infection Control Department, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China, 050051)
出处
《分子诊断与治疗杂志》
2017年第2期137-141,146,共6页
Journal of Molecular Diagnostics and Therapy
基金
河北省卫生厅重点科技研究研究计划(20150271)
