三阴乳腺癌患者的临床病理特征及预后情况分析

Clinicopathological Characteristics and Prognosis Analysis of Patients with TNBC

目的探讨三阴乳腺癌(triple negative breast cancer,TNBC)患者的临床病理特征及预后情况。方法选取2009年7月—2011年7月收治的360例乳腺癌患者的病例资料,按免疫组织化学检测结果分为非三阴性乳腺癌(nTNBC)组和TNBC组,每组180例。比较两组的临床病理资料,从而对TNBC组临床病理特征及预后情况进行分析。结果两组患者的发病年龄、临床分期、肿瘤病灶直径、淋巴结转移和组织学分级比较差异具有统计意义(P<0.01,P<0.05)。TNBC组局部复发率和远端转移率高于nTNBC组(P<0.01,P<0.05)。TNBC组无病生存率和总生存率均低于nTNBC组(P<0.05)。结论 TNBC多见于50岁以上的女性,肿瘤分化差、恶性程度高,患者手术预后效果不佳,死亡率较其他类型乳腺癌疾病高。

Objective To investigate clinicopathological characteristics and prognosis of patients with triple negative breast cancer （TNBC）. Methods Clinical data of 360 patients with TNBC admitted during July 2009 and July 2011 was recruited in these study, and the patients were divided into non-TNBC group （nTNBC group, n = 180） and TNBC group （n = 180） according to immunohistochemistry resuhs. Clinicopathological characteristics of the two groups were compared, and clinicopathological characteristics and prognosis of TNBC were analyzed. Results There were significant differences in age of onset, clinical stage, tumor diameter, lymph node metastasis and histological grade in two groups （P 〈 0.01, P 〈 0.05）. Local recurrence and distant metastasis rates in TNBC group were significantly higher than those in nTNBC group （ P 〈 0. 01, P 〈 0. 05）. The disease-free survival and overall survival rates in TNBC group were significantly lower than those in nTNBC group （P 〈 0.05）. Conclusion TNBC is more common in women over 50 years old with characteristics such as poor tumor differentiation, high malignancy degree and poor prognosis, and its mortality rate is higher than other types of breast cancer.