胞外囊泡在配子成熟中作用的研究进展

Research progress on the role of extracellular vesicles in gamete maturation

细胞外囊泡(EVs)是细胞在激活或凋亡过程中释放的一种超微膜性囊泡,可运载多种蛋白质、脂质、DNA及RNAs等,为细胞间通讯提供了一种新方式。越来越多的研究表明,EVs通过不同机制在配子成熟过程中发挥重要作用。现就EVs在精子和卵子成熟过程中作用的研究进展做一综述。

Extracellular vesicles （EVs） are ultrastructural membraneous vesicles,released from activated or apoptic cells,that carry various proteins,lipids,DNAs and RNAs.EVs provide a bandy new way of cell-to-cell communication.More and more evidences have demonstrated that EVs may play important roles in various physiological and pathological processes including gamate maturation.This article reviews some of research progress and application prospect on function and mechanism of EVs in sperm and oocyte maturation.