小鼠早产模型的研究进展

Advances in mouse model for preterm birth

早产是世界范围内导致5岁以下儿童死亡的首要原因,同时早产会增加儿童神经功能发育障碍和成年后患慢性疾病的风险,因此探讨早产发生机制对儿童健康具有重要意义。早产(PTB)是一个多因素导致的综合征,具体发生机制尚不清楚。由于伦理学的限制,基于人类的早产实验研究困难,因此采用动物模型来验证临床观察假说十分重要。自上世纪九十年代起,小鼠成为研究早产的主要动物,本文综述了几种常用的建立小鼠早产模型的方法,包括激素模型、感染模型、炎症模型等,并对其效率和优缺点进行了比较分析,为早产的基础和临床研究提供一定的参考依据。

Preterm birth （PTB） is the leading cause of worldwide cause of death for children under 5-year old,at the same time increases the risk ofpreterm children＆#39;s neurological development disorders and chronic diseases in adulthood,so explore the mechanisms of PTB is important for children＆#39;s health.PTB is a multifactorial syndrome;the specific mechanism is unclear now.Due to limitations of ethics,experimental studies in humans PTB is difficult,so using animal models to validate clinical observation is very important.Since 1990s,the mice become the main animal model of PTB,several methods commonly used are reviewed here,including models of hormones,infection,inflammation,at the same time we compared their efficiency,advantages and disadvantages,to provide reference for the basic and clinical research on PTB.