左西孟坦对急性心力衰竭患者NT-proBNP、RDW、hs-CRP、LVEF水平的影响

Effects of Levosimendan on NT - proBNP,RDW,hs - CRP andLVEF Levels in Patients with Acute Heart Failure

目的 观察左西孟坦对急性心力衰竭患者NT-proBNP、RDW、hs-CRP、LVEF水平的影响.方法选取2014年1月~2016年1月在我院进行治疗的急性心力衰竭患者108例,按治疗方法分为2组,各54例.对照组实施常规治疗,研究组在常规治疗基础上采用左西孟坦进行治疗,分析比较两组患者N末端B型钠尿肽前体（NT-proBNP）、超敏C反应蛋白（hs-CRP）、红细胞分布宽度（RDW）、左室射血分数（LVEF）水平.结果治疗前,两组患者NT-proBNP、RDW、hs-CRP、LVEF水平无明显差异（P〉0.05）;治疗7 d后,研究组患者NT-proBNP、RDW、hs-CRP水平较对照组明显降低,差异显著（P〈0.05）;研究组LVEF水平明显高于对照组,差异显著（P〈0.05）.结论急性心力衰竭患者采用左西孟坦治疗效果显著,可有效改善患者NT-proBNP、RDW、hs-CRP、LVEF水平,促进患者病情恢复,改善患者生活质量,具有临床应用价值.

Objective To explore effects of levosimendan on NT - proBNP, RDW, hs - CRP and LVEF Levels in patients with acute heart failure. Methods 108 patients with acute heart failure who were treated in our hospital from Jan. 2014 to Jan. 2016 were randomly divided into two groups with 54 cases in each group. Routine treatment was used in control group. Patients in observation group were treated with levosimendan on the basis of routine treatment. NT - proBNP,hs - CRP, RDW and LVEF were analyzed and compared. Results There was no significant difference in NT -proBNP, RDW, hs -CRP and LVEF between the two groups before treatment（P 〉 0.05 ）. NT- proBNP, RDW and hs - CRP significantly decreased in observation group than those in control group after 7 d treatment （ P 〈 0. 05 ）. LVEF was significantly higher in observation group than that in control group（P 〈 0.05）. Conclusion Levosimendan is effective for patients with acute heart failure, which can effectively improve NT - proBNP, RDW, hs - CRP and LVEF levels, promote body recovery and improve quality of life for patients.