Del Nido心肌保护液在儿童心脏手术中的应用

Application of Del Nido cardioplegia solution during pediatric cardiac surgery

先天性心脏病的治疗大多需要在心脏停止跳动的情况下行心脏直视手术矫正畸形。心肌保护液使心脏的电机械活动停止、在低温环境下提供代谢底物、减少心肌缺血和再灌注损伤，发挥重要的心肌保护作用。由于未成熟心肌和成熟心肌具有较多差异，有针对性的选择对未成熟心肌有利的心肌保护液不仅关系到手术的成功，更重要的是关系到患儿的术后康复。近年来心肌保护液的配方及灌注方式也在不断的改进。Del Nido心肌保护液是美国最常用的一种，它已有近20年的历史，不仅对降低儿童心脏手术的死亡率和并发症发生率具有重要作用，也在成人心脏手术中使用和推广，但目前在国内尚未普及。本文将对Del Nido心肌保护液在儿童心脏手术中的应用作详细介绍。

For most congenital heart diseases, heart beating has to be stopped to allow surgical correction of cardiac deformity. Cardioplegia is one of the important methods of myocardial protection with the goals of stopping electromechanical activity, supplying metabolic substrates during hypothermia and lessening myocardial ischemia-reperfusion injury. In light of numerous differences between immature and mature myocardial tissues, selectingk an optimal cardioplegia solution is of vital importance. It is correlated with both operative success and postoperative rehabilitatiorL In recent years, composition and delivery method of cardioplegia solution have underwent constant improvements. Del Nido cardioplegia solution has been commonly applied at pediatric cardiac centers across the United States for almost two decades. It plays an important role of lowering the mortality and complications during pediatric cardiac surgery. And Del Nido cardioplegia has expanded successfully into adult cardiac centers over the last decade. However, its popularity has stayed low in China where Del Nido cardioplegia is reserved for pediatric cardiac surgery. So the application of Del Nido cardioplegia solution during pediatric candiac surgery was included in this article.