益生菌减少婴幼儿频繁喘息的初步观察

Effects of probiotics on reduction of the episode of recurrent wheezing in infants

目的探讨益生菌对减少婴幼儿频繁喘息的临床疗效。方法按照真实世界研究(real world research,RWR)原则,对诊断为婴幼儿喘息患儿,发作次数≥6次/年且其家长拒绝接受规则吸入糖皮质激素(ICS)或白三烯受体拮抗剂(顺尔宁)预防治疗者,根据家长意愿分为观察组和对照组。2010年1月至2013年6月入组患儿共84例,其中观察组41例,对照组43例,坚持按要求服药随访1年以上者观察组33例,对照组31例(分别脱落8例和12例)。两组患儿均在其喘息发作给予ICS、顺尔宁、抗组胺药等短期治疗,观察组在喘息间歇期给予双歧四联活菌片(0.5 g/次,3次/d),疗程6个月,对照组不予任何预防性用药。观察用药后两组患儿在1年间喘息发作次数的差异。结果用药后1年,观察组和对照组喘息发作次数分别为(2.81±1.24)次和(5.22±2.29)次,差异有统计学意义(t=5.23,P<0.05)。结论对于婴幼儿频繁喘息,长期应用益生菌制剂,可减少其喘息发作次数。

Objective To discuss the clinical effects of probiotics on the reduction of the episode of recurrent wheezing in infants.Methods Based on the principles of the Real World Research,84 patients diagnosed as infantile wheezing,who had at least six episodes of wheezing per year and refused to accept inhaled corticosteroids（ICS） or leukotriene receptor antagonists（Singulair） regularly,were enrolled and divided into the observation group（41 cases） or control group（43 cases） according to the choices of their parents.33 cases in the observed group vs 31 cases in the control group completed the study.ALL the patients received a short-term treatment with ICS,montelukast and antihistamines during the wheezing episode;the observation group was additionally given viable bifidobacterium quadruple 0.5 tid between the episodes.The treatment course was 6 months.The frequency of wheezing episode in both groups within one year after treatment were observed.Results The frequency of wheezing episode was（2.81 ± 1.24） times in the observation group vs（5.22 ± 2.29） times in the control group（t=5.23,P〈0.05）.Conclusion Probiotics can reduce the frequency of wheezing episode in infants with recurrent wheezing.