穿心莲内酯对毛细支气管炎患儿临床疗效及细胞因子影响的研究

Study on the effect of andrographolide on children with bronchiolitis clinical curative effect and cytokines

目的观察穿心莲内酯治疗毛细支气管炎的疗效,分析穿心莲内酯对毛细支管炎患儿血清Th17、Th1和Th2型细胞因子的影响,探讨穿心莲内酯的免疫调节作用。方法临床观察85例毛细支气管炎患儿,穿心莲内酯(45例)和利巴韦林(40例)治疗毛细管支气炎的7d有效率,ELISA法测定各组血清IL-17、IFN-γ、IL-10的水平。结果穿心莲内酯组总有效率高于利巴韦林组,差异有统计学意义(P<0.05);穿心莲内酯组治疗后IL-17和IL-10水平低于治疗前,差异有统计学意义(P<0.05)。结论穿心莲内酯能有效治疗毛细支管炎,并能抑制Th17和Th2型细胞因子。

Objective To observe the curative effect of andrographolide in the treatment of bronchiolitis,analysis of the effect of andrographolide on capillary bronchitis in children with Th17,Th1 and Th2 type cytokines,andrographolide immunomodulatory effects are discussed. Observation of 85 case clinical curative effect of andrographolide and ribavirin in the treatment of capillaritis,ELISA determination of serum IL-17 and IFN-and IL-10 levels. Results in andrographolide group without efficiency is lower than ribavirin group,the difference was statistically significant（P〈0.05）,in andrographolide group the total efficiency is higher than that of ribavirin group,the difference was statistically significant（P〈0.05）;andrographolide group after treatment of IL-17 and IL-10 levels higher than the treatment,the difference is statistically significant（P〈0.05）. Conclusion andrographolide can be effective in the treatment of capillary bronchitis,and inhibit Th17 and Th2 cytokines.