心境障碍女性患者血浆白蛋白、总胆红素和尿酸水平研究

Study on plasma albumin,total bilirubin and uric acid in female patients with mood disorder

目的探讨心境障碍女性患者血浆白蛋白、总胆红素、尿酸水平的变化及其临床意义。方法纳入2014年3月至2016年7月在湖北省人民医院精神科收治的心境障碍女性患者117例作为研究对象,其中抑郁发作53例、躁狂发作64例;另选择42例同期女性健康体检者作为正常对照。对比分析其血浆白蛋白、总胆红素和尿酸水平的差异。结果心境障碍患者的白蛋白水平为(42.02±2.85)g/L,明显低于对照组的(44.65±2.68)g/L,差异有统计学意义(P<0.05);抑郁组患者的白蛋白水平为(41.12±2.64)g/L,明显低于躁狂组的(42.76±2.81)g/L,且二者均低于对照组,差异均有统计学意义(P<0.05);抑郁组患者的血浆总胆红素为(10.49±4.72)μmol/L,明显低于对照组的(12.34±3.78)μmol/L,差异有统计学意义(P<0.05);躁狂组患者的尿酸水平为(320.33±78.46)μmol/L,明显高于抑郁组的(278.85±65.62)μmol/L和对照组的(286.05±49.37)μmol/L,差异均有统计学意义(P<0.05),而抑郁组尿酸水平和对照组相当,差异无统计学意义(P>0.05)。结论心境障碍女性患者存在抗氧化能力降低和氧化应激损伤,女性躁狂发作患者还可能存在嘌呤代谢紊乱。

Objective To explore the changes of plasma albumin, total bilirubin and uric acid in female patients with mood disorder and their clinical significance. Methods A total of 117 patients with mood disorder including53 depression patients and 64 mania patients, who admitted to Renmin Hospital of Wuhan University from March 2014 to July 2016, were selected as research subjects. At the same time, 42 cases of healthy women were chosen as the control group. The plasma albumin, total bilirubin and uric acid levels were compared and analyzed. Results The level of plasma albumin in mood disorder group was（42.02±2.85） g/L, which was significantly lower than（44.65±2.68） g/L in the control group（P〈0.01）. The level of plasma albumin in depression patients was（41.12±2.64） g/L, which was significantly lower than（42.76±2.81） g/L in mania patients（P〈0.05）, and both were significantly lower than that in the control group（P〈0.05）. The level of total bilirubin of mood disorder patients was（10.49 ± 4.72） μ mol/L, which was significantly lower than（12.34 ± 3.78） μ mol/L in the control group（P〈0.05）. The level of uric acid in mania patients was（320.33 ± 78.46） μ mol/L,which was significantly higher than（278.85±65.62） μmol/L in the depression patients and（286.05±49.37） μmol/L in the control group（P〈0.05）. There was no significant difference between the mood disorder patients and the control group in the level of uric acid（P〉0.05）. Conclusion The female patients with mood disorders have antioxidant defense system disorder, and female mania patients may also have purine metabolic disorders.