苯甲酸雌二醇对卵巢早衰患者骨代谢及骨密度的影响

Effect of estradiol benzoate on bone metabolism and bone mineral density of patients with premature ovarian failure

目的探讨采用苯甲酸雌二醇治疗卵巢早衰患者时对患者骨代谢以及骨密度的影响。方法选取2014年2月-2015年2月在医院进行治疗的卵巢早衰患者100例作为治疗组,按照随机数字表方法分为治疗1组和治疗2组各50例;选取同期在医院进行体检的健康女性100例作为对照组。治疗1组的患者采用苯甲酸雌二醇进行治疗,治疗2组的患者采用雌激素联合醋酸甲羟孕酮序贯治疗。比较各组患者治疗前、后的骨代谢以及骨密度相关指标(包括腰椎骨密度、股骨颈骨密度、25-羟基维生素D3、骨钙素),比较各组患者治疗前、后的临床相关指标(包括雌二醇、血糖、三酰甘油、总胆固醇)。结果治疗1组患者经治疗后腰椎骨密度、股骨颈骨密度显著低于对照组,差异有统计学意义(P<0.05);治疗2组患者经治疗后腰椎骨密度、股骨颈骨密度、25-羟基维生素D3水平显著低于对照组,差异有统计学意义(P<0.05);治疗后治疗1组患者的腰椎骨密度、股骨颈骨密度、25-羟基维生素D3水平显著高于治疗2组患者,骨钙素水平显著低于治疗2组患者,雌二醇水平显著高于治疗2组患者,胆固醇水平显著低于治疗2组患者,差异均有统计学意义(P<0.05)。结论对卵巢早衰的患者采用苯甲酸雌二醇进行治疗,能够很好地促进患者骨密度的增加,降低骨质疏松的发生率,并且不会造成严重的不良反应。

Objective To explore the effect of estradiol benzoate on bone metabolism and bone mineral density（BMD） of patients with premature ovarian failure（POF）.Methods One hundred patients with POF treated in the hospital from February 2014 to February2015 were selected as treatment group,then they were divided into treatment one group and treatment two group according to random number table,50 cases in each group;one hundred healthy women after physical examination during the same period in the hospital were selected as control group.The cases in treatment one group were treated by estradiol benzoate,while the cases in treatment two group were treated by sequential therapy of estrogen combined with medroxyprogesterone.Bone metabolism and BMD related indexes（including lumbar BMD,femoral neck BMD,25-hydroxy vitamin D3,osteocalcin）,clinically relevant indicators（including estradiol,blood glucose,triacylglycerol,total cholesterol） before and after treatment were compared.Results Lumbar BMD and femoral neck BMD after treatment in treatment one group were statistically significantly lower than those in control group（P〈0.05）;lumbar BMD,femoral neck BMD,25-hydroxy vitamin D3 level after treatment in treatment two group were statistically significantly lower than those in control group（P〈0.05）;after treatment,lumbar BMD,femoral neck BMD,25-hydroxy vitamin D3 level in treatment one group were higher than those in treatment two group,osteocalcin level in treatment one group was lower than that in treatment two group,estradiol level in treatment one group was higher than that in treatment two group,cholesterol level in treatment one group was lower than that in treatment two group,there were statistically significant differences（P〈0.05）.Conclusion Estradiol benzoate can promote the increase of BMD of patients with POF,reduce the incidence rate of osteoporosis without serious adverse reactions.