人参皂苷Rb1巴布剂对微血管舒缩活动振幅影响的研究

On the Effect of Ginsenoside Rb1 Babu Agent on the Amplitude of Microvascular Vasomotion

目的:探究人参皂苷Rb1巴布剂对微血管舒缩活动的影响。方法:运用智能透皮仪进行人参皂苷Rb1巴布剂体外透皮,收集接受液并用高效液相色谱分析。将巴布剂贴敷在志愿者的穴位区皮肤上,利用激光多普勒血流仪测定,并记录贴敷含药巴布剂前后穴位区皮内微血管的舒缩运动振幅。结果:随着透皮时间的延长,人参皂苷Rb1的累积透过率增多。人参皂苷Rb1巴布剂穴位贴敷引起微血管舒缩活动振幅均有显著提高(P<0.01)。结论:人参皂苷Rb1巴布剂给药系统可释放药物进入穴位区,提高穴位区皮内微血管舒缩运动振幅,达到针灸的效果,因此人参皂苷Rb1可以在临床上代替针灸,治疗疾病。

Objective： To study the effect of ginsenoside Rb1 Babu agent on the amplitude of microvascular vasomotion. Methods： The transdermal permeation of ginsenoside Rb1 Babu agent in vitro was performed by using intelligent transdermal apparatus, and the percutaneous fluid was collected and analyzed by using high performance liquid chromatography（HPLC）. The Babu agent was stuck on acupoint of volunteers, determinated by Laser Doppler Flowmeter, and amplitude of microvascular vasomotion of acupoint was recorded. Results： With the extension of transdermal time, the cumulative transmittance of ginsenoside Rb1 increased. The amplitude of microvascular vasomotion could be significantly increased with the application of ginsenoside Rb1 Babu agent（P〈0.01）. Conclusion： The drug delivery system of ginsenoside Rb1 Babu can release the drug into the acupoint, increase the amplitude of microvascular vasomotion, and achieve the effect of acupuncture. Therefore, ginsenoside Rb1 Babu agent can be used to treat disease and replace acupuncture clinically.