齐拉西酮联合改良性电休克治疗首发精神分裂症患者的疗效及对患者代谢的影响

Influence of ziprasidone combined with amend electric shock on efficacy and metabolism of patients with first-episode schizophrenia

目的探讨齐拉西酮联合改良性电休克对首发精神分裂症患者的疗效及代谢的影响。方法选择2013年7月—2016年7月新乡医学院第二附属医院收治的86例首发精神分裂症患者,根据随机数字表法,分为观察组及对照组,观察组给予齐拉西酮联合改良性电休克治疗,对照组给予奥氮平联合改良性电休克治疗。观察对比两组患者的PANSS总评分、CGI评分、总有效率、不良反应、体质指数(BMI)、糖代谢及脂代谢。结果治疗后,两组的PANSS总评分、CGI评分均明显下降,且组间对比差异无统计学意义;两组总有效率对比无明显差异;治疗后两组TESS评分均明显降低,治疗后观察组的TESS评分明显低于对照组(P<0.05);与治疗前比较,治疗后观察组的BMI、空腹血糖、三酰甘油、总胆固醇、高/低密度脂蛋白、胰岛素水平均无明显变化,而对照组的BMI、空腹血糖、三酰甘油、总胆固醇、低密度脂蛋白、胰岛素水平与治疗前相比显著升高;观察组治疗后BMI、空腹血糖、三酰甘油、总胆固醇、胰岛素水平明显低于对照组(P<0.05)。结论奥氮平与齐拉西酮联合改良型电休克治疗首发精神分裂症患者均有显著疗效,而齐拉西酮的不良反应及代谢副反应少,值得临床推广应用。

Objective To investigate the influence of ziprasidone combined with amend electric shock on the efficacy and metabolism of patients with first-episode schizophrenia. Methods According to random number table, 86 cases with first-episode schizophrenia from July 2013 to July 2016 in the Second Affiliated Hospital of Xinxiang Medical University were chosen and divided into observation group and control group. The patients in observation group were given ziprasidone combined with first-episode schizophrenia, the patients in control group were taken with olanzapine combined with first-episode schizophrenia. The PANSS total score, CGI score, total efficacy, adverse reaction, body mass index, glycometabolism, and lipid metabolism of two groups were observed and compared. Results The PANSS score, CGI score of two groups were all obvious decreased, which had no significant difference, the total efficacy of two groups had no significant difference; The TESS scores were all decreased, and the TESS score of observation group was obviously lower than that of control group（P〈0.05）. Compared with before treatment, the BMI, fasting blood sugar, triglyceride, total cholesterol, high/low density lipoprotein and fasting insulin level of observation group after treatment had no obvious significant difference, while the BMI, fasting blood sugar, triglyceride, total cholesterol, low density lipoprotein, and fasting insulin levels of control group had obvious significant difference, and the BMI, fasting blood sugar, triglyceride, total cholesterol, and fasting insulin of observation group were obviously lower than control group（P〈0.05）. Conclusion Olanzapine and ziprasidone combined with amend electric shock have obvious efficacy on patients with first-episode schizophrenia, while the ziprasidone had lower adverse reaction and metabolic side effects, which is worth of clinical promotion and application.