盐酸氨溴索雾化吸入治疗新生儿肺炎的疗效分析

Efficacy of ambroxol hydrochloride inhalation in treatment of infantile pneumonia

目的探讨盐酸氨溴索雾化吸入治疗新生儿肺炎的疗效。方法选取80例肺炎患儿,按随机数字表法分为两组,对照组(39例)常规抗感染、止咳等综合治疗,观察组(41例)在对照组治疗基础上,给予盐酸氨溴索雾化吸入,观察并记录两组患者疗效、临床症状消失时间、红细胞压积、血液黏稠度及治疗期间不良反应情况,评价盐酸氨溴索雾化吸入对新生儿肺炎的疗效。结果治疗后观察组有效率高于对照组(P<0.05),观察组38例患儿,对照组28例患儿治疗后咳嗽、憋喘减轻,痰量减少;盐酸氨溴索雾化吸入治疗后,观察组患儿咳嗽、肺部湿啰音消失时间及平均住院时间明显缩短(P<0.05);治疗后观察组患者红细胞压积、血液黏稠度均低于对照组(P<0.05);治疗期间两组不良反应率无统计学差异。结论盐酸氨溴索雾化吸入对新生儿肺炎具有较好的治疗效果,能迅速改善肺炎症状,降低血液黏稠度,用药安全,值得临床推广使用。

Objective To discuss the efficacy of ambroxol hydrochloride inhalation in treatment of infantile pneumonia. Methods Totally 80 pneumonia infants were selected and randomly divided into two groups. The control group（39 cases） were given anti-infection, cough-relieved, and other treatment. The observation group（41 cases） were given ambroxol hydrochloride inhalation on the basis of control group treatment. The efficacy of ambroxol hydrochloride inhalation in treatment of infantile pneumonia was evaluated by efficacy, clinical symptoms disappearing time, red blood cell hematocrit, blood viscosity, and adverse reaction during treatment. Results After treatment, the effective rate of observation group was higher than that of control group（P〈0.05）. There were 38 infants in observation group and 28 infants in control group with cough and dyspnea alleviated and phlegm reduced. After atomizing inhalation of ambroxol hydrochloride, the cough, pulmonary rales disappearing time and hospitalization time were significantly shortened（P〈0.05）. After treatment, the red blood cell hematocrit and blood viscosity of observation group was lower than that of control group（P〈0.05）. During treatment, there was no statistical significance on adverse reaction between two groups. Conclusion Ambroxol hydrochloride inhalation has a good curative effect on infantile pneumonia. It could improve the symptoms of pneumonia and reduce blood viscosity with good safety, which is worthy of clinical use.