糖尿病患者无症状性低糖血症的神经影像学研究进展

Progress on Neurological Imaging Examination for Diabetic Asymptomatic Hypoglycemia

低糖血症是糖尿病常见并发症之一,无症状性低糖血症是指患者无典型低糖血症症状但血糖≤3.9mmol/L,其在老年2型糖尿病患者中较为常见,如处理不及时则会危及患者生命安全。脑功能成像技术通过观察局部脑灌注、葡萄糖摄取或代谢率等而反映脑局部活动变化,有助于分析无症状性低糖血症患者大脑功能特性及其对脑皮质功能的影响,进而指导临床治疗等。本文对糖尿病患者无症状性低糖血症的神经影像学研究进展进行综述。

Hypoglycemia is one of common complications of diabetes, asymptomatic hypoglycemia means blood glucose equal or less than 3.9 mmol/L without typical hypoglycemia symptoms; asymptomatic hypoglycemia is common in elderly patients with type 2 diabetes mellitus, which will endanger the patients＇ life without timely intervention. Brain functional imaging technology can reflect the changes of local brain activity by observing local cerebral peffusion, glucose uptake rate or glucose metabolic rate, is helpful to analyze the brain functional characteristics and the impact on cortex function in diabetes patients complicated with asymptomatic hypoglycemia, and then provide reference for the clinical treatment. This paper reviewed the progress on neurological imaging examination for diabetic asymptomatic hypoglycemia.