血清孕酮及β-hCG检测在诊断早期先兆流产中的临床研究

Clinical studies of serum progesterone and β-h CG detection in the diagnosis of early threatened abortion

目的统计分析血清孕酮及β-hCG检测在早期诊断先兆流产中的临床意义。方法选取2015年1月~2016年10月在我院住院治疗的阴道出血患者作为研究对象,其中先兆流产及流产组各100例患者,同时选取同期的100例正常孕妇作为对照组研究对象,观察患者在入院时血清孕酮及β-hCG水平;先兆流产组经过2周治疗以后的血清孕酮及β-hCG水平;灵敏度、特异度、阳性预期值、阴性预期值。结果先兆流产组和流产组的血清孕酮及β-hCG水平均明显低于对照组,三组比较差异具有统计学意义(P<0.05);且流产组的血清孕酮及β-hCG水平又明显低于先兆流产组,两组比较差异具有统计学意义(P<0.05);继续妊娠组研究对象血清孕酮≥30ng/m L及β-HCG≥5000m IU/m L的患者数明显要高于流产的患者例数,两组比较差异具有统计学意义(P<0.05);血清孕酮水平以30ng/m L进行区分,敏感度及特异度分别为84.00%和80.00%;β-hCG以5000m IU/m L进行区分,敏感度及特异度分别为80.00%和100.00%;血清孕酮及β-hCG水平联合进行观察,敏感度及特异度分别为90.00%和96.00%。结论血清孕酮及β-hCG水平联合观察,可有效提高诊断的灵敏度及特异度,尽早进行保胎治疗,提高保胎成功率。

Objective To statistically analyze the clinical significance of serum progesterone and β -hCG detection in early diagnosis of threatened abortion. Methods Bleeding patients hospitalized in our hospital vagina from January 2015 to October 2016 were selected as the research object.100 cases were divided into threatened abortion group,100 cases were divided into abortion group,and 100 cases of normal pregnant women were selected as control group at the same time.The serum progesterone level HCG betaon admission,and threatened abortion group after 2 weeks after treatment the level of serum progesterone and β-hCG,and sensitivity,specificity,positive predictive value,negative predictive value were observed. Results The serum progesterone and β-hCG levels of threatened abortion group and abortion group were significantly lower than those of control group,there were significant differences between the 3 groups （P 〈 0.05）. And the serum progesterone and β-hCG of abortion group were significantly lower thn the level of threatened abortion group, there were significant differences between the 2 groups （P 〈 0.05）. The number of patients whose serum progesterone was more than 30ng/ml and beta -HCG was 5000mfU/ml in pregnancy group was significantly higher than abortion group, there were significant differences between the 2 groups （P 〈 0.05）. Serum progesterone levels were differentiated by 30ng/mL,the sensitivity and specificity were 84.00% and 80.00%; β-hCG were distinguished by 5000mIU/mL,the sensitivity and specificity respectively were 80.00% and 100%.And the level of serum progesterone β-hCG joint were observed.The sensitivity and specificity were 90.00% and 96.00%. Conclusion The serum progesterone level and β-hCG joint observation can effectively improve the diagnostic sensitivity and specificity,tocolytie therapy as soon as possible,and improve the success rate of miscarriage.