艾滋病孕产妇的抗反转录病毒治疗与人类免疫缺陷病毒母婴阻断相关性探讨

Correlation study between anti-retroviral therapy and human immunodeficiency virus associated with AIDS PMTCT maternal

目的研究分析患艾滋病产妇的抗反转录病毒治疗与人类免疫缺陷病毒母婴阻断相关性。方法将2013年6月~2016年4月我院收治的40例艾滋病孕妇随机纳入对照组(维乐命方案)和观察组(高效抗反转录病毒治疗方案)中,每组20例,观察记录所有患者在治疗后的临床效果。结果观察组无HIV阳性出现,对母婴传播阻断有效率为100%。两组患者孕36周和治疗3个月后血浆病毒载量下降程度及CD4+T淋巴细胞水平升高程度均存在统计学差异(P<0.05)。结论对患艾滋病产妇进行高效抗反转录病毒治疗的临床疗效较好,能够对有效抑制病毒且使CD4+T淋巴细胞水平升高,可见该疗法具有较高的临床应用价值,值得推广。

Objective To explore the correlation between anti-retroviral therapy and human immunodeficiency virus associated with AIDS PMTCT maternal. Methods 40 pregnant women infected with human immunodefieiency virus from June 2013 to April 2016 in our hospital which were divided into observation group （20 patients, viramnne program） and control group （20 patients, highly active anti-retroviral program） respectively. The clinical efficacy and incidence of adverse reactions of all the patients were obversed and recorded. Results The observation group had no HIV positive; and mother to child transmission blocking efficiency was 100%. After 36 weeks and after treatment for 3 months, there were significant difference on the decline of viral load and the increase ratio of CD4^＋T lymphocyte between the two groups, and there were statistical significances （P 〈 0.05）. Conclusion Highly active anti-retroviral program for mother-to-child transmission can effectively suppress the virus, and increase the CD4^＋T lymphocyte level significantly. It means that this program is valuable in the clinical applications and deserves the promotion.