急性心肌梗死早期血清超敏C反应蛋白和前白蛋白与并发急性心力衰竭的关系研究

Relationship research of serum high sensitivity C reactive protein, prealbumin in early acute myocardial infarction and complicated acute heart failure

目的为了进一步提高临床对急性心肌梗死并急性心力衰竭患者的确诊率及有效预防并发症的发生,探讨和研究早期检测血清超敏C反应蛋白和白蛋白的必要性和意义。方法将来我院心内科就诊的80例急性心肌梗死并急性心力衰竭患者作为研究对象并归为观察组,根据双盲对照的原则随机抽取同时间段来我院心内科就诊的健康者作为对照组研究对象,即急性心肌梗死组和健康组,观察组患者均给予清淡饮食、抗血小板、调酯、扩冠等对症治疗,分别测定两组患者的超敏C反应蛋白(hs-CRP)及血清前白蛋白含量(PA)并进行对比分析。结果经过对数据进行统计学分析得出,观察组患者体内超敏C反应蛋白含量和对照组相比明显升高,而血清前白蛋白含量(PA)和观察组相比则显著降低,且两组比较差异有统计学意义(P<0.05)。结论临床上对怀疑有急性心肌梗死并急性心力衰竭患者进行早期检测hs-CRP及PA含量,有利于及时地发现病情变化,采取有效治疗措施并预防并发症的发生,值得推广和应用。

Objective In order to improve the diagnostic accuracy of acute myocardial infarction and acute heart failure and effective prevention of complications, to explore and study the necessity and significance of early detection of serum high-sensitivity C reactive protein and albumin. Methods 80 patients with acute myocardial infarction complicated with acute heart failure cured in Internal Medicine-Cardiovascular Department of our hospital were selected as the study objects, and they were as observation group. According to the＇principle of double blind control, healthy subjects cured in Department of Cardiology in our hospitalover the same period of time were randomly selected as control group. Those were acute myocardial infarction group and healthy group. Patients in observation group were treated with light diet, anti platelet, ester, crown and other symptomatic treatment. High sensitivity C reactive protein （hs-CRP） and serum prealbumin （PA） of the two groups were detected and compared. Results Statistical analysis of the data showed that the content of high sensitive C reactive protein in the observation group was significantly higher than that in the control group, the serum prealbumin （PA） was significantly lower than that of the observation group, and the difference between the two groups Was statistically significant （P 〈 0.05）. Conclusion The early detection of hs-CRP and PA in patients with suspected acute myocardial infarction and acute heart failure is conducive to timely detection of changes in the disease and effective treatment and prevention of complications. It is worthy of promotion and application.