免疫功能缺陷对儿童反复呼吸道感染的影响

Effect of immune deficiency on children with recurrent respiratory tract infection

目的探究免疫功能缺陷对儿童反复呼吸道感染的影响。方法选取2014年1月~2016年8月在我院接受治疗的反复呼吸道感染患儿96例,作为实验组,同时选取门诊体检健康儿童62例为对照组,检测并比较两组血清免疫球蛋白及IgG亚类水平。结果 RRTI组患儿的血清IgG2和IgG4水平均低于对照组(P<0.05);在3~5岁时,实验组和对照组的IgA分别为(1.05±0.51)、(1.50±0.52)g/L,实验组低于对照组,数据差异具有统计学意义(P<0.05);96例RRTI患儿中IgG亚类缺陷共17例,检出率为48.9%(47/96)。结论 IgG亚类等免疫功能缺陷对儿童反复呼吸道感染的影响较大,应及时的预防和监测,以提高患儿的免疫力,预防反复呼吸道感染的发生。

Objective To explore the effect of immune deficiency on children with recurrent respiratory iract infection. Methods 96 cases of recurrent respiratory tract infection in our hospital from January 2014 to Aguest 2016 were selected as the RRTI group, 62 cases were selected as the control group, The immunoglobulin and IgG subclasses of the two groups were detected and compared. Results The serum levels of IgG2 and IgG4 in RRTI group were lower than those in control group（P 〈 0.05）. At the age of 3-5, IgA of RRTI group and control group were （1.05 ± 0.51） and （1.50 ± 0.52）g/L, the RRTI group was lower than the control group, and the data was statistically significant difference（P 〈 0.05）. Among the 96 cases of RRTI in children, there were 17 cases of IgG subclass deficiency, and the detection rate was 48.9% （47/96）. Conclusion IgG subclass and other immune function defects has greater influence on children with recurrent respiratory tract infection. It should be timely prevention and monitoring to improve the immunity of the children, and to prevent the occurrence of recurrent respiratory tract infections.