肠道微生态参与肠易激综合征发病的相关机制

Mechanism of Involvement of Intestinal Microbiota in Pathogenesis of Irritable Bowel Syndrome

肠易激综合征(IBS)的病因和发病机制尚未明了,近年认为肠道微生态可能发挥重要作用。有研究表明IBS患者存在肠道菌群改变,干预肠道微生态对IBS有一定的治疗作用。本文就肠道微生态通过改变黏膜通透性、激活免疫反应、改变胃肠动力和影响脑-肠轴等参与IBS发病的相关机制作一综述。

The etiology and pathogenesis of irritable bowel syndrome（ IBS） are not fully understood,and intestinal microbiota had been assumed as a possible factor in the pathogenesis of IBS. Increasing evidences have shown that alterations of gut microbiota were found in IBS patients and modulation of intestinal microbiota might be effective in the treatment of IBS. This article reviewed the mechanism of involvement of intestinal microbiota in pathogenesis of IBS by altering mucosal permeability,activating immune reaction,disturbing gastrointestinal motility and affecting brain-gut axis.