PFOS对斑马鱼的急性毒性及安全浓度评价

Acute Toxicity and Safe Concentration Assessment of Perfluorooctane Sulfonate(PFOS) to Danio rerio

[目的]探讨全氟辛烷磺酸(PFOS)对斑马鱼的生态毒性效应。[方法]采用静态染毒法研究不同浓度的PFOS暴露对斑马鱼的急性毒性效应。[结果]不同浓度PFOS暴露条件下斑马鱼出现鱼体侧翻、失去平衡、游泳能力和和呼吸能力减弱等中毒现象,随着PFOS暴露浓度的增加和暴露时间的延长,斑马鱼的死亡率也相应增加,存在明显的剂量效应和时间效应关系。PFOS对斑马鱼24、48、72、96 h的半致死浓度(LC_(50))分别为26.09、9.08、3.91和2.58 mg/L,安全浓度为0.258 mg/L。根据急性毒性分级标准,判断PFOS对斑马鱼的毒性为高毒。[结论]该研究结果可为掌握PFOS的生态毒性以及评价其生态风险和危害提供科学依据。

[ Objective] To investigate the ecological toxicity effects of perfluorooctane sulfonates （PFOS） on Danio rerio. [ Method ] The acute toxicity effects of different concentrations of PFOS on D. rerio were studied by using static exposure method. [ Result] The toxic symptoms of D. rerio appeared under the exposure of different concentrations of PFOS such as body roll, loss of equilibrium, declined swimming ability and respiratory ability. The death rate of D. rerio enhanced with increase of PFOS concentration and prolonging of exposure time, and there were obvious dose-response and time-response correlatious. LC50 of PFOS to D. rerio at 24 , 48 , 72 , 96 h were 26.09, 9.08, 3.91, 2.58mg/L, respectively. The safe concentration of PFOS to D. rerio was 0. 258 mg/L. According to the grading standard of acute toxicity, the toxicity of PFOS to D. rerio belonged to high toxicity. [ Conclusion] The research results can provide scientific basis for studying the eco- logical toxicity of PFOS and evaluating its ecological risk and hazards.