回顾性分析哮喘预测指数对儿童哮喘治疗效果及肺功能的影响

Retrospective analysis of impact of asthma predictive index on therapeutic effect and pulmonary function in children with asthma

目的探索哮喘预测指数(asthma predictive index,API)对哮喘治疗效果及肺功能的影响。方法将我院儿科哮喘专科门诊就诊诊断为哮喘并进行标准治疗1年的126例儿童,按照API严格标准划分为阳性组76例,阴性组50例,统计学分析治疗1年前、后肺功能测定值(X5、Fres、R5、R20、R5-R20),另选取健康儿童47例为健康对照组。结果治疗前API阳性组与阴性组肺功能各指标比较差异无统计学意义(P>0.05),且均较正常对照组差(P<0.05)。治疗1年后阳性组肺功能X5、Fres、R5、R20值较前有明显改善(P<0.05),但R5-R20值与治疗前差异无统计学意义(P<0.05)。阴性组治疗前后肺功能测定值均有明显改善(P<0.05)。治疗1年后两组间X5、Fres、R20测定值差异无统计学意义(P>0.05),但阳性组R5、R5-R20值大于阴性组,差异有统计学意义(P<0.05)。API阳性组哮喘控制率、部分控制率、未控制率分别为62%、26%、9%;阴性组控制率、部分控制率、未控制率分别为80%、12%、8%,阴性组哮喘控制情况优于阳性组(P<0.01)。结论 API阳性组肺功能改善及哮喘控制情况较阴性组差。

Objective To investigate the impact of asthma predictive index on therapeutic effect and pulmo- nary function in children with asthma. Methods 126 cases were treated with standard treatment for 1 years in the pediatric asthma specialist outpatient clinic of our hospital, and according to the strict standard of API, 76 cases were divided into the API positive group and 50 cases in the API negative group. The value of pulmonary function （ XS, Fres, RS, R20, R5 - R20） before and 1 year after treatment were analyzed statistically. 47 healthy children were se- lected as the healthy control group. Results There was no significant difference between the API positive group and the negative group in lung function index before treatment （ P 〉 0. 05 ） , but the two groups were worse than the control group （ P 〈 0. 05）. 1 year after treatment, ）（5, Fres, Pt5 and R20 values of the positive group improved significantly improved compared with the former （ P 〈 0. 05 ）, but there was no significant difference in the value of R5 - R20 （ P 〉 0. 05 ）. Before and after treatment, the lung function test values improved significantly in the negative group （ P 〈 0. 05 ）. There was no significant difference in the measured values of XS, Fres and R20 between the two groups after 1 years （ P 〉 0.05 ） , but R5 and R5 - R20 value were higher in the positive group than in the negative group （ P 〈 0. 05）. The complete control rate, partial control rate, and uncontrolled rate in the API positive group were 62% , 26% and 9% , respectively, while the rates in the negative group were 80% , 12% and 8% , respectively, and the control of asthma in the negative group was better than that in the positive group （ P 〈 0. 05 ）. Conclusion The im- provement of lung function and the control of asthma in the API positive group are worse than those in the negative group.