儿童支气管哮喘患者血清骨桥蛋白和嗜酸细胞趋化因子表达及临床意义

Study on serum osteopontin and eotaxin expression in children with bronchial asthma and its clinical significance

目的研究支气管哮喘患儿血清骨桥蛋白(OPN)和嗜酸细胞趋化因子(Eotaxin)的表达情况,探讨支气管哮喘发病机制。方法 89例支气管哮喘患儿为研究对象,观察急性期与缓解期血清骨桥蛋白、嗜酸细胞趋化因子及嗜酸性粒细胞(Eos)的检测情况,以49例健康儿童为对照组。研究骨桥蛋白、嗜酸细胞趋化因子与嗜酸性粒细胞的相关性。结果支气管哮喘急性期、缓解期以及对照组三组骨桥蛋白、嗜酸细胞趋化因子与嗜酸性粒细胞依次降低。组间差异均有统计学意义;支气管哮喘患儿骨桥蛋白(r=0.635)、嗜酸细胞趋化因子(r=0.678)与嗜酸性粒细胞均呈正相关。结论骨桥蛋白、嗜酸细胞趋化因子及嗜酸性粒细胞的研究于支气管哮喘发病机制的研究以及治疗均提供了一个新的角度,对支气管哮喘的防治有重要的临床价值。

] Objective To study the expression of serum osteopontin （OPN） and eosinophil chemotactic fac- tor （Eotaxin） in bronchial asthma children, and to explore the pathogenesis of bronchial asthma. Methods 89 patients with bronchial asthma were selected to observe the levels of serum osteopontin, eosinophil chemotaxis factor and eosinophil eosinophil （EOS） during acute and remission period. Another 49 healthy children were taken as the control group. The correlation between osteopontin and eosinophils eotaxin level and eosinophils was studied. Results The level of osteopontin （ OPN）, eosinophil chemotaxis factor and EOS decreased gradually in the acute group, the remission group and the control group. Osteopontin （ r = 0. 552） and eosinophil chemotactic factor （ r = 0. 678 ） were positively correlated with eosinophil eosinophil. Conclusion The detection of osteopontin, eosinophil chemotactic factor and eosinophile granulocyte provides a new point of view in the pathogenesis of bronchial asthma research and treatment, which has important clinical value on prevention and treatment of bronchial asthma.