血必净对重度颅脑外伤患者免疫系统的影响研究

Clinical study on the effect of Xuebijing on immune system in patients with severe craniocerebral trauma

目的研究血必净治疗对重度颅脑外伤患者免疫系统的影响。方法临床纳入78例我院2015年1月-2016年1月期间收治的重度颅脑外伤患者作为研究对象,所有患者技随机数字表法分为两组咅39例。其中39例患者采用常规综合性治疗作为对照组、另39例患者在上述基础上联合血必净治疗作为研究组。观察两组患者治疔后免疫系统指标变化情况以及不良反应情况。结果治疗前两组患者细胞免疫水平均无差异(P>0.05);治疗后研究组HLA-DR、CD3^+以及CD4^+水平均高于对照组,CD8^+水平则低于对照组(P<0.05)。治疗前两组患者体液免疫水平均无差异(P>0.05);治疗后两组患者IgA、IgG、IgM以及C4水平仍无差异(P>0.05);而研究组C3水平则低于对照组(P<0.05)。研究组、对照组不良反应发生率分别为7.69%、10.26%,两组对比无差异(P>0.O5)。结论血必净可明显提高重度颅脑外伤患者的免疫功能,增加患者抵抗力,促进治疔效果.改善患者预后,安全性高,值得临床应用及推广。

Objective To study the effect of Xuebijing treatment on immune system in patients with severe cranioeere- bral trauma. Methods A total of 78 patients with severe craniocerebral trauma admitted in our hospital from January 2015 to January 2016 were enrolled in this study. All patients were divided into two groups according to the random number table, with 39 cases in each group. 39 patients treated with conventional comprehensive treatment were chosen as the control group, and the other 39 patients were selected as the study group, who treated with Xuebijing on the ba- sis of the basic treatment. The changes of the immune system indexes and the adverse reactions were observed between the two groups after treatment. Results There was no significant difference in the cellular immunity between the two groups before treatment （P〉0.05）. The levels of HLA-DR, CD3＋ and CD4＋ in the study group were higher than those in the control group after treatment, while the level of CD8＋ in the study group was lower than that in the control grouP（P〈 0.05）. There was no significant difference in humoral immunity between the two groups before treatment（P〉0.05）. There was still no significant difference in IgA, IgG, IgM and C4 levels between the two groups after treatment（P〉0.05）. While the level of C3 in the study group was lower than that in the control group（P〈0.05）. The incidence of adverse reactions in the study group and the control group was 7.69% and 10.26% respectively. There was no significant difference be- tween the two groups（P〉0.05）. Conclusion Xuebijing can significantly improve the immune function of patients with severe cranioeerebral trauma, increase patient resistance, promote the treatment effect, improve the prognosis of pa- tients, high safety, worthy of clinical application and promotion.