糖皮质激素局部鼓室内注射法治疗难治性突聋的临床效果

Clinical effect of glucocorticoids local intratympanic injection in the treatment of refractory sudden deafness

目的研究并探讨糖皮质激素局部鼓室内注射治疗难治性突聋的临床效果。方法选取2013年1月-2016年10月期间我院收治的60例难治性突聋患者作为研究对象,采取单盲随机分组法将患者随机分为两组,各30例、两组患者均选用地塞米松治疗,对照组经耳后沟局部注射给药、观察组经鼓室穿刺注射给药,比较两组患者的临床总有效率、听力、不良反应发生率。结果观察组患者的治疗总有效率为63.33%,与对照组的56.67%相比,差异无统计学意义(P>0.05),两组均有较好的疗效。治疗后,两组患者的听阈均明显降低(P<0.05),但观察组患者的听力提高程度优于对照组患者(P<0.05)。治疗期间,两组患者的不良反应发生率比较无统计学差异(P>0.05)。结论局部鼓室内注射糖皮质激素治疗难治性突聋的疗效较为显著,可有效提高患者的听力水平。

Objective To study and explore the clinical effect of glucocorticoid local intratympanic injection in the treatment of refractory sudden deafness. Methods A total of 60 patients with refractory sudden deafness treated in our hospital from January 2013 to October 2016 were selected and divided into two groups with 30 cases in each group, ac- cording to single-blind random grouping method. Patients in two groups were both treated with dexamethasone. The control group was treated by the ear ditch local injection, and the observation group was treated by tympanic puncture injection. Clinical total efficiency, hearing and the incidence of adverse reactions between the two groups were com- pared. Results There was no statistically significant difference in the total effective rate between the treatment group （63.33%） and the control group（56.67%） （P〉0.05）, and the two groups both had good effect. After treatment, the hearing thresholds of the two groups were significantly lower （P〈0.05）, but the improvement degree of hearing in the observation group was better than that of the control group （P〈0.05）. There was no significant difference in the incidence of adverse reactions between the two groups（P〉0.05）. Conclusion Local tympanic injection of glucocortieoid in the treatment of re- fractory sudden deafness is significantly effective, and can effectively improve the patient＇s hearing.