盐酸维拉帕米治疗心绞痛的不良反应回归分析

Regression analysis of adverse reactions of verapamil hydrochloride in the treatment of angina pectoris

目的探讨临床使用维拉帕米片发生药物不良反应的影响因素。方法收集本院124例维拉帕米片不良反应患者资料,对患者使用维拉帕米的临床特点和影响因素进行统计分析。结果不良反应发生率男性高于女性;发生不良反应的患者中累及的系统和器官以心血管不良反应的比例最高(38.71%),其次是神经系统不良反应(31.45%)。维拉帕米片不良反应的可疑因素主要为患者的性别、年龄、用药频率、服药剂量、疗程、合并用药和既往过敏史。结论应用盐酸维拉帕米治疗心绞痛,需要对患者的年龄,既往过敏史和病史进行详细的了解,才能保障用药安全。

Objective To explore the suspected influencing factors of adverse drug reactions of the clinical application of verapamil tablets. Methods Data of 124 patients with adverse reactions due to the administration of verapamil tablets were collected in our hospital. The clinical characteristics and influencing factors of verapamil were analyzed statistically. Results The incidence of adverse reactions was higher in males than in females; the proportion of cardiovascular adverse reactions was the highest among the affected systems and organs in the patients with adverse reactions （38.71%）, followed by the nervous system adverse reactions（31.45%）. The suspected factors of the adverse effects of verapamil tablets were mainly gender, age, frequency of administration, dose, course of treatment, drug combination and past history of allergies. Conclusion The application of verapamil hydrochloride in the treatment of angina pectoris needs to have a detailed understanding of the age, past history of allergies and disease history of the patients, in order to ensure the safety of medication.