年轻乳腺浸润性导管癌患者乳腺X线及超声检查特征与分子分型相关性研究

Correlations Between Mammography and Ultrasound and Molecular Classification of Breast Infiltrating Ductal Carcinoma in Young Women

目的评估年轻乳腺浸润性导管癌患者乳腺X线钼靶检查、乳腺彩超检查的特征与分子分型的相关性。方法回顾性研究笔者医院2011年1月~2016年5月经治的94例≤40岁的乳腺浸润性导管癌患者的影像学、临床病理学特点。94例患者均有乳腺超声检查结果及乳腺X线检查结果。结果乳腺超声检查中,基底样型多为卵圆形或圆形肿块,腔面型多为不规则肿块(P=0.000)。基底样型边缘多为小分叶状、浸润状,腔面型多为有锐角、星芒状(P=0.000)。基底样型多为边境明显区分,腔面A型多有声晕(P=0.000)。乳腺X线检查中,HER-2阳性型多表现为仅有钙化,基底样型多表现为肿块(P=0.002)。腔面型肿块多呈星芒状或遮蔽型边缘,基底样型多呈浸润性边缘(P=0.000)。结论年轻浸润性导管癌患者乳腺影像学检查特征与分子分型有一定相关性。

Objective To determine the correlations between breast ultrasonic and mammographic features and molecular classifica- tion of breast infiltrating ductal carcinoma in young women. Methods A retrospective review of radiological, clinic - pathology features of breast cancers for women under 40 years at our hospital between January 2011 and May 2016 covering 94 patients. Mammography and ultrasound were available for all 94 patients. Results On sonography, basal like type turnouts more often appeared as oval or round masses and microlobulated or indistinct margins luminal type irregular mass and angular or spiculated margins（ P = 0. 000 ,P = 0. 000）. Basal like type masses were often with abrupt interface, luminal A type with echogenic halo （ P = 0. 000）. On mamography, HER - 2 enriched type cancers more presented as microcal cification only, basal like type more masses（ P = 0. 002）. Luminal type masses were more often with spiculated or obscured margins, basal like with indistinct margins （ P = 0. 000）. Conclusion The imaging charasteristics of breast infiltrating ductal carcinoma in patients under 40 years appear correlated to breast infiltrating ductal carcinoma.