帕夫林胶囊联合甲氨蝶呤治疗干燥综合征的临床观察

Clinical observation of Palmer Fu Lin Capsules combined with Methotrexate in the treatment of Sjgren syndrome

目的探讨帕夫林胶囊(白芍总苷胶囊)联合甲氨蝶呤治疗干燥综合征(SS)的临床效果。方法选取2014年2月~2016年5月北京大学深圳医院收治的100例干燥综合征患者为研究对象,依据治疗措施的不同分为对照组和联合治疗组,每组50例对照组给予甲氨蝶呤4粒/次,1次/周;联合治疗组在对照组基础上联合应用帕夫林胶囊2粒/次,2次/d,两组患者均治疗6个月。比较两组干燥综合征患者治疗前后类风湿因子、血沉、C反应蛋白、唾液流率、Schirmer试验、血清γ-球蛋白、凝血指标水平及临床疗效。结果两组治疗前类风湿因子、血沉、C反应蛋白、唾液流率、Schirmer试验、血清γ-球蛋白、活化部分凝血酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)、凝血酶时间(TT)、D-二聚体(D-D)水平比较,差异无统计学意义(P>0.05)。两组治疗前后APTT、PT、TT水平比较,差异无统计学意义(P>0.05)。治疗后,两组类风湿因子、血沉、C反应蛋白、唾液流率、Schirmer试验、血清γ-球蛋白、FIB、D-D均低于治疗前(P<0.05),联合治疗组类风湿因子、血沉、C反应蛋白、唾液流率、Schirmer试验、血清γ-球蛋白、FIB、D-D均低于对照组(P<0.05),联合治疗组临床治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论帕夫林胶囊联合甲氨蝶呤治疗干燥综合征患者临床症状改善明显,效果良好,值得临床推广应用。

Objective To explore clinical effect of Palmer Fu Lin Capsules combined with Methotrexate in the treatment of Sjogren syndrome （SS）.Methods 100 patients with SS were selected as the research object in the Shenzhen Hospital of Peking University from February 2014 to May 2016 and divided into control group and combined treatment group ac- cording to treatment measures,50 cases in each group.The control group were treated with methotrexate 2.5 mg/tablet, each time 4 tablets,1 time a week;the combined treatment group were treated with Palmer Fu Lin Capsules each time 2 tablets,2 times/d on the basis of the control group,patients of two groups were treated for 6 months.Rheumatoid factor （RF）,ESR,C reactive protein （CRP）,salivary flow rate,Schirmer test,serum 7-globulin,blood coagulation index level be- fore and after treatment,and clinical curative effect were compared between two groups.Results RF,ESR,CRP,saliva flow rate,Schirmer test,serum γ-globulin,aetivated partial thromboplastin time （APTT）,prothrombin time （PT）,fibrinogen （FIB）,thrombin time （TT）,D-Dimer （D-D） between two groups before treatment had no difference （P〉0.05）.APTT,PT,TT in two groups before and after treatment had no difference （P〉0.05）;RF,ESR,CRP,saliva flow rate,Schirmer test,serum γ- globulin,FIB,D-D after treatment in two groups was lower than that before treatment （P〈0.05）.RF, ESR,CRP,saliva flow rate,Schirmer test,serum γ-globulin,FIB,D-D of the combined treatment group was lower than that of the control group （P〈0.05）.The total effective rate of the combined treatment group was higher than that of the control group,the differ- ence was statistical significance （P〈0.05）.Conclusion Clinical symptoms of Palmer Fu Lin Capsules combined with Methotrexate in the treatment of （SS） improve obviously,clinical effect is good,it is worthy of clinical application.