摘要
目的探讨急性ST段抬高型心肌梗死应用阿替普酶溶栓治疗的效果。方法选取2012年10月~2015年10月我院诊治的152例急性ST段抬高型心肌梗死患者,采用随机数字表法分为对照组和观察组,每组76例,对照组采用尿激酶治疗,观察组采用阿替普酶治疗,于治疗前后行心电图检测,分析不同时间点心血管再通情况,比较两组患者的临床疗效、不良反应。结果治疗后,两组患者Q波时间、Q波/R波、ST段偏移较治疗前降低(P<0.01);观察组患者的Q波时间[(0.042±0.009)d]、Q波/R波(0.31±0.06)、ST段偏移[(3.20±0.57)m V]低于对照组[(0.051±0.010)d、0.36±0.05、(4.35±0.61)m V](P<0.01)。组内同时间点比较,发病时间≤6 h患者心血管再通率高于发病时间>6 h患者(P<0.05);组间同时间点比较,观察组心血管再通率高于对照组(P<0.05)。观察组患者治疗总有效率高于对照组(97.4%vs.82.9%)(P<0.01)。观察组患者不良反应发生率低于对照组(2.6%vs.13.2%),差异有统计学意义(P<0.05)。结论阿替普酶溶栓治疗急性ST段抬高型心肌梗死的效果显著,且安全性高,值得临床推广应用。
Objective To investigate effect of Aheplase thrombolysis in the treatment of ST-segment elevation acute my- ocardial infarction.Methods 152 patients with ST-segment elevation acute myocardial infarction treated in our hospital from October 2012 to October 2015 were selected and divided into control group and observation group by random number table method,76 cases in each group.Patients in the control group were treated with Urokinase,while patients in the observation group treated with Aheplase.Electrocardiogram was detected before and after treatment.Cardiovascular reperfusion was analyzed at different time points.Clinical efficacy and adverse reactions were compared between two groups.Results Compared with before treatment,Q wave time,Q wave/R wave,ST segment deviation after treatment was decreased in two groups (P〈0.01);Q wave time [(0.042±0.009) d],Q wave/R wave (0.31±0.06),ST segment deviation [(3.20± 0.57) mV] in the observation group was lower than that in the control group [(0.051±0.010) d,0.36±0.05,(4.35±0.61) mV] (P〈0.01).Compared at same time points in the group,cardiovascular reperfusion rate of patients with onset time ≤6 h was higher than that of patients with onset time〉6 h (P〈0.05);compared at same time points between two groups,cardio- vascular reperfusion rate in the observation group was higher than that in the control group (P〈0.05).Total effective rate in the observation group was higher than that in the control group (97.4% vs. 82.9%) (P〈0.01).Incidence of adverse re- actions in the observation group was lower than that in the control group (2.6% vs. 13.2%),and the difference was sta- tistically significant (P〈0.O5).Conclusion Alteplase thrombolysis has significant effect in the treatment of ST-segment elevation acute myocardial infarction,which has high safety,which is worthy of clinical application.
出处
《中国当代医药》
2017年第7期50-52,共3页
China Modern Medicine